PDB entry 1w3c

View 1w3c on RCSB PDB site
Description: Crystal structure of the Hepatitis C Virus NS3 Protease in complex with a peptidomimetic inhibitor
Class: hydrolase
Keywords: hydrolase, serine protease, hcv, indoline-based peptidomimetic inhibitor
Deposited on 2004-07-14, released 2004-12-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-09-23, with a file datestamp of 2015-09-18.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protease/helicase ns3 (p70)
    Species: Hepatitis C virus (isolate 1) [TaxId:11104]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1w3c.1
  • Chain 'B':
    Compound: protease/helicase ns3 (p70)
    Species: Hepatitis C virus (isolate 1) [TaxId:11104]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1w3c.2
  • Chain 'C':
    Compound: nonstructural protein ns4a (p4)
    Species: HEPATITIS C VIRUS (ISOLATE 1), synthetic [TaxId:11104]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1w3c.1
  • Chain 'D':
    Compound: nonstructural protein ns4a (p4)
    Species: HEPATITIS C VIRUS (ISOLATE 1), synthetic [TaxId:11104]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1w3c.2
  • Heterogens: DN1, DN2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1w3cA (A:)
apitaysqqtrgllgciitsltgrdknqvdgevqvlstatqsflatcvngvcwtvyhgag
sktlagpkgpitqmytnvdqdlvgwpappgarsmtpctcgssdlylvtrhadvipvrrrg
dsrgsllsprpvsylkgssggpllcpsghvvgifraavctrgvakavdfipvesmettmr
spvftdn

    Sequence, based on observed residues (ATOM records): (download) 
    >1w3cA (A:)
itaysqqtrgllgciitsltgrdknqvdgevqvlstatqsflatcvngvcwtvyhgagsk
tlagpkgpitqmytnvdqdlvgwpappgarsmtpctcgssdlylvtrhadvipvrrrgds
rgsllsprpvsylkgssggpllcpsghvvgifraavctrgvakavdfipvesme

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1w3cB (B:)
apitaysqqtrgllgciitsltgrdknqvdgevqvlstatqsflatcvngvcwtvyhgag
sktlagpkgpitqmytnvdqdlvgwpappgarsmtpctcgssdlylvtrhadvipvrrrg
dsrgsllsprpvsylkgssggpllcpsghvvgifraavctrgvakavdfipvesmettmr
spvftdn

    Sequence, based on observed residues (ATOM records): (download) 
    >1w3cB (B:)
itaysqqtrgllgciitsltgrdknqvdgevqvlstatqsflatcvngvcwtvyhgagsk
tlagpkgpitqmytnvdqdlvgwpappgarsmtpctcgssdlylvtrhadvipvrrrgds
rgsllsprpvsylkgssggpllcpsghvvgifraavctrgvakavdfipvesme

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1w3cC (C:)
kgsvvivgriilsgrk

    Sequence, based on observed residues (ATOM records): (download) 
    >1w3cC (C:)
gsvvivgriilsg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1w3cD (D:)
kgsvvivgriilsgrk

    Sequence, based on observed residues (ATOM records): (download) 
    >1w3cD (D:)
gsvvivgriilsg