PDB entry 1vzo
View 1vzo on RCSB PDB site
Description: the structure of the n-terminal kinase domain of msk1 reveals a novel autoinhibitory conformation for a dual kinase protein
Class: transferase
Keywords: protein kinase, transferase, phosphorylation, serine/threonine protein kinase
Deposited on
2004-05-21, released
2004-06-11
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.208
AEROSPACI score: 0.47
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: ribosomal protein s6 kinase alpha 5
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 1VZO
- engineered mutation (218)
- Uniprot O75582
Domains in SCOPe 2.08: d1vzoa_ - Heterogens: BME, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1vzoA (A:)
mahhhhhheeeggssggaagtsadggdggeqlltvkhelrtanltghaekvgienfellk
vlgtgaygkvflvrkisghdtgklyamkvlkkativqkakttehtrterqvlehirqspf
lvtlhyafqtetklhlildyinggelfthlsqrerftehevqiyvgeivlalehlhklgi
iyrdiklenilldsnghvvltdfglskefvadeteraydfcgtieymapdivrggdsghd
kavdwwslgvlmyelltgaspftvdgeknsqaeisrrilkseppypqemsalakdliqrl
lmkdpkkrlgcgprdadeikehlffqkinwddlaakkvpapfkpvirdeldvsnf
Sequence, based on observed residues (ATOM records): (download)
>1vzoA (A:)
qlltvkhelrtanltghaekvgienfellkvlgtgaygkvflvrkisghdtgklyamkvl
kkativqkakttehtrterqvlehirqspflvtlhyafqtetklhlildyinggelfthl
sqrerftehevqiyvgeivlalehlhklgiiyrdiklenilldsnghvvltdfglskefv
adeteraydfcgtieymapdivrggddkavdwwslgvlmyelltgaspftvdgeknsqae
isrrilkseppypqemsalakdliqrllmkdpkkrlgcgprdadeikehlffqkinwddl
aakkvpapfkpvirdeldv