PDB entry 1v5b

View 1v5b on RCSB PDB site
Description: The Structure Of The Mutant, S225A and E251L, Of 3-Isopropylmalate Dehydrogenase From Bacillus Coagulans
Class: oxidoreductase
Keywords: 3-isopropylmalate dehydrogenase, IPMDH, mutant, S225A/E251L, Bacillus coagulans, homo dimer, X-ray analysis, crystal structure, OXIDOREDUCTASE
Deposited on 2003-11-22, released 2005-02-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: 0.214
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Bacillus coagulans [TaxId:1398]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12010 (0-End)
      • engineered (224)
      • engineered (250)
    Domains in SCOPe 2.08: d1v5ba_
  • Chain 'B':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Bacillus coagulans [TaxId:1398]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12010 (0-End)
      • engineered (224)
      • engineered (250)
    Domains in SCOPe 2.08: d1v5bb_
  • Chain 'C':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Bacillus coagulans [TaxId:1398]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12010 (0-End)
      • engineered (224)
      • engineered (250)
    Domains in SCOPe 2.08: d1v5bc_
  • Chain 'D':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Bacillus coagulans [TaxId:1398]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12010 (0-End)
      • engineered (224)
      • engineered (250)
    Domains in SCOPe 2.08: d1v5bd_
  • Chain 'E':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Bacillus coagulans [TaxId:1398]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12010 (0-End)
      • engineered (224)
      • engineered (250)
    Domains in SCOPe 2.08: d1v5be_
  • Chain 'F':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Bacillus coagulans [TaxId:1398]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12010 (0-End)
      • engineered (224)
      • engineered (250)
    Domains in SCOPe 2.08: d1v5bf_
  • Chain 'G':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Bacillus coagulans [TaxId:1398]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12010 (0-End)
      • engineered (224)
      • engineered (250)
    Domains in SCOPe 2.08: d1v5bg_
  • Chain 'H':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Bacillus coagulans [TaxId:1398]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12010 (0-End)
      • engineered (224)
      • engineered (250)
    Domains in SCOPe 2.08: d1v5bh_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1v5bA (A:)
mkmklavlpgdgigpevmdaairvlktvldndgheavfenaliggaaideagtplpeetl
dicrrsdaillgavggpkwdhnpaslrpekgllglrkemglfanlrpvkayatllnaspl
krervenvdlvivreltgglyfgrpserrgpgenevvdtlaytreeieriiekafqlaqi
rrkklasvdkanvlessrmwreiaeetakkypdvelshmlvdstamqlianpgqfdvivt
enmfgdilsdlasvitgslgmlpsaslrsdrfgmyepvhgsapdiagqgkanplgtvlsa
almlrysfglekeaaaiekavddvlqdgyctgdlqvangkvvstieltdrlieklnnsaa
gprifq

    Sequence, based on observed residues (ATOM records): (download) 
    >1v5bA (A:)
mkmklavlpgdgigpevmdaairvlktvldndgheavfenaliggaaideagtplpeetl
dicrrsdaillgavggpkwdhnpaslrpekgllglrkemglfanlrpvkayatllnaspl
krervenvdlvivreltgglyfgrpserrgpgenevvdtlaytreeieriiekafqlaqi
rrkklasvdkanvlessrmwreiaeetakkypdvelshmlvdstamqlianpgqfdvivt
enmfgdilsdlasvitgslgmlpsaslrsdrfgmyepvhgsapdiagqgkanplgtvlsa
almlrysfglekeaaaiekavddvlqdgyctgdlqvangkvvstieltdrliekln

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1v5bB (B:)
mkmklavlpgdgigpevmdaairvlktvldndgheavfenaliggaaideagtplpeetl
dicrrsdaillgavggpkwdhnpaslrpekgllglrkemglfanlrpvkayatllnaspl
krervenvdlvivreltgglyfgrpserrgpgenevvdtlaytreeieriiekafqlaqi
rrkklasvdkanvlessrmwreiaeetakkypdvelshmlvdstamqlianpgqfdvivt
enmfgdilsdlasvitgslgmlpsaslrsdrfgmyepvhgsapdiagqgkanplgtvlsa
almlrysfglekeaaaiekavddvlqdgyctgdlqvangkvvstieltdrlieklnnsaa
gprifq

    Sequence, based on observed residues (ATOM records): (download) 
    >1v5bB (B:)
mkmklavlpgdgigpevmdaairvlktvldndgheavfenaliggaaideagtplpeetl
dicrrsdaillgavggpkwdhnpaslrpekgllglrkemglfanlrpvkayatllnaspl
krervenvdlvivreltgglyfgrpserrgpgenevvdtlaytreeieriiekafqlaqi
rrkklasvdkanvlessrmwreiaeetakkypdvelshmlvdstamqlianpgqfdvivt
enmfgdilsdlasvitgslgmlpsaslrsdrfgmyepvhgsapdiagqgkanplgtvlsa
almlrysfglekeaaaiekavddvlqdgyctgdlqvangkvvstieltdrlieklnn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1v5bC (C:)
mkmklavlpgdgigpevmdaairvlktvldndgheavfenaliggaaideagtplpeetl
dicrrsdaillgavggpkwdhnpaslrpekgllglrkemglfanlrpvkayatllnaspl
krervenvdlvivreltgglyfgrpserrgpgenevvdtlaytreeieriiekafqlaqi
rrkklasvdkanvlessrmwreiaeetakkypdvelshmlvdstamqlianpgqfdvivt
enmfgdilsdlasvitgslgmlpsaslrsdrfgmyepvhgsapdiagqgkanplgtvlsa
almlrysfglekeaaaiekavddvlqdgyctgdlqvangkvvstieltdrlieklnnsaa
gprifq

    Sequence, based on observed residues (ATOM records): (download) 
    >1v5bC (C:)
mkmklavlpgdgigpevmdaairvlktvldndgheavfenaliggaaideagtplpeetl
dicrrsdaillgavggpkwdhnpaslrpekgllglrkemglfanlrpvkayatllnaspl
krervenvdlvivreltgglyfgrpserrgpgenevvdtlaytreeieriiekafqlaqi
rrkklasvdkanvlessrmwreiaeetakkypdvelshmlvdstamqlianpgqfdvivt
enmfgdilsdlasvitgslgmlpsaslrsdrfgmyepvhgsapdiagqgkanplgtvlsa
almlrysfglekeaaaiekavddvlqdgyctgdlqvangkvvstieltdrliekln

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1v5bD (D:)
mkmklavlpgdgigpevmdaairvlktvldndgheavfenaliggaaideagtplpeetl
dicrrsdaillgavggpkwdhnpaslrpekgllglrkemglfanlrpvkayatllnaspl
krervenvdlvivreltgglyfgrpserrgpgenevvdtlaytreeieriiekafqlaqi
rrkklasvdkanvlessrmwreiaeetakkypdvelshmlvdstamqlianpgqfdvivt
enmfgdilsdlasvitgslgmlpsaslrsdrfgmyepvhgsapdiagqgkanplgtvlsa
almlrysfglekeaaaiekavddvlqdgyctgdlqvangkvvstieltdrlieklnnsaa
gprifq

    Sequence, based on observed residues (ATOM records): (download) 
    >1v5bD (D:)
mkmklavlpgdgigpevmdaairvlktvldndgheavfenaliggaaideagtplpeetl
dicrrsdaillgavggpkwdhnpaslrpekgllglrkemglfanlrpvkayatllnaspl
krervenvdlvivreltgglyfgrpserrgpgenevvdtlaytreeieriiekafqlaqi
rrkklasvdkanvlessrmwreiaeetakkypdvelshmlvdstamqlianpgqfdvivt
enmfgdilsdlasvitgslgmlpsaslrsdrfgmyepvhgsapdiagqgkanplgtvlsa
almlrysfglekeaaaiekavddvlqdgyctgdlqvangkvvstieltdrlieklnn

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1v5bE (E:)
mkmklavlpgdgigpevmdaairvlktvldndgheavfenaliggaaideagtplpeetl
dicrrsdaillgavggpkwdhnpaslrpekgllglrkemglfanlrpvkayatllnaspl
krervenvdlvivreltgglyfgrpserrgpgenevvdtlaytreeieriiekafqlaqi
rrkklasvdkanvlessrmwreiaeetakkypdvelshmlvdstamqlianpgqfdvivt
enmfgdilsdlasvitgslgmlpsaslrsdrfgmyepvhgsapdiagqgkanplgtvlsa
almlrysfglekeaaaiekavddvlqdgyctgdlqvangkvvstieltdrlieklnnsaa
gprifq

    Sequence, based on observed residues (ATOM records): (download) 
    >1v5bE (E:)
mkmklavlpgdgigpevmdaairvlktvldndgheavfenaliggaaideagtplpeetl
dicrrsdaillgavggpkwdhnpaslrpekgllglrkemglfanlrpvkayatllnaspl
krervenvdlvivreltgglyfgrpserrgpgenevvdtlaytreeieriiekafqlaqi
rrkklasvdkanvlessrmwreiaeetakkypdvelshmlvdstamqlianpgqfdvivt
enmfgdilsdlasvitgslgmlpsaslrsdrfgmyepvhgsapdiagqgkanplgtvlsa
almlrysfglekeaaaiekavddvlqdgyctgdlqvangkvvstieltdrliekln

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1v5bF (F:)
mkmklavlpgdgigpevmdaairvlktvldndgheavfenaliggaaideagtplpeetl
dicrrsdaillgavggpkwdhnpaslrpekgllglrkemglfanlrpvkayatllnaspl
krervenvdlvivreltgglyfgrpserrgpgenevvdtlaytreeieriiekafqlaqi
rrkklasvdkanvlessrmwreiaeetakkypdvelshmlvdstamqlianpgqfdvivt
enmfgdilsdlasvitgslgmlpsaslrsdrfgmyepvhgsapdiagqgkanplgtvlsa
almlrysfglekeaaaiekavddvlqdgyctgdlqvangkvvstieltdrlieklnnsaa
gprifq

    Sequence, based on observed residues (ATOM records): (download) 
    >1v5bF (F:)
mkmklavlpgdgigpevmdaairvlktvldndgheavfenaliggaaideagtplpeetl
dicrrsdaillgavggpkwdhnpaslrpekgllglrkemglfanlrpvkayatllnaspl
krervenvdlvivreltgglyfgrpserrgpgenevvdtlaytreeieriiekafqlaqi
rrkklasvdkanvlessrmwreiaeetakkypdvelshmlvdstamqlianpgqfdvivt
enmfgdilsdlasvitgslgmlpsaslrsdrfgmyepvhgsapdiagqgkanplgtvlsa
almlrysfglekeaaaiekavddvlqdgyctgdlqvangkvvstieltdrlieklnn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1v5bG (G:)
mkmklavlpgdgigpevmdaairvlktvldndgheavfenaliggaaideagtplpeetl
dicrrsdaillgavggpkwdhnpaslrpekgllglrkemglfanlrpvkayatllnaspl
krervenvdlvivreltgglyfgrpserrgpgenevvdtlaytreeieriiekafqlaqi
rrkklasvdkanvlessrmwreiaeetakkypdvelshmlvdstamqlianpgqfdvivt
enmfgdilsdlasvitgslgmlpsaslrsdrfgmyepvhgsapdiagqgkanplgtvlsa
almlrysfglekeaaaiekavddvlqdgyctgdlqvangkvvstieltdrlieklnnsaa
gprifq

    Sequence, based on observed residues (ATOM records): (download) 
    >1v5bG (G:)
mkmklavlpgdgigpevmdaairvlktvldndgheavfenaliggaaideagtplpeetl
dicrrsdaillgavggpkwdhnpaslrpekgllglrkemglfanlrpvkayatllnaspl
krervenvdlvivreltgglyfgrpserrgpgenevvdtlaytreeieriiekafqlaqi
rrkklasvdkanvlessrmwreiaeetakkypdvelshmlvdstamqlianpgqfdvivt
enmfgdilsdlasvitgslgmlpsaslrsdrfgmyepvhgsapdiagqgkanplgtvlsa
almlrysfglekeaaaiekavddvlqdgyctgdlqvangkvvstieltdrlieklnn

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1v5bH (H:)
mkmklavlpgdgigpevmdaairvlktvldndgheavfenaliggaaideagtplpeetl
dicrrsdaillgavggpkwdhnpaslrpekgllglrkemglfanlrpvkayatllnaspl
krervenvdlvivreltgglyfgrpserrgpgenevvdtlaytreeieriiekafqlaqi
rrkklasvdkanvlessrmwreiaeetakkypdvelshmlvdstamqlianpgqfdvivt
enmfgdilsdlasvitgslgmlpsaslrsdrfgmyepvhgsapdiagqgkanplgtvlsa
almlrysfglekeaaaiekavddvlqdgyctgdlqvangkvvstieltdrlieklnnsaa
gprifq

    Sequence, based on observed residues (ATOM records): (download) 
    >1v5bH (H:)
mkmklavlpgdgigpevmdaairvlktvldndgheavfenaliggaaideagtplpeetl
dicrrsdaillgavggpkwdhnpaslrpekgllglrkemglfanlrpvkayatllnaspl
krervenvdlvivreltgglyfgrpserrgpgenevvdtlaytreeieriiekafqlaqi
rrkklasvdkanvlessrmwreiaeetakkypdvelshmlvdstamqlianpgqfdvivt
enmfgdilsdlasvitgslgmlpsaslrsdrfgmyepvhgsapdiagqgkanplgtvlsa
almlrysfglekeaaaiekavddvlqdgyctgdlqvangkvvstieltdrlieklnn