PDB entry 1v16

View 1v16 on RCSB PDB site
Description: crosstalk between cofactor binding and the phosphorylation loop conformation in the bckd machine
Class: oxidoreductase
Keywords: oxidoreductase,ketoacid dehydrogenase, branched-chain, multi-enzyme complex, acylation, oxidative decarboxylation maple syrup urine disease, thiamine diphosphate , phosphorylation, flavoprotein
Deposited on 2004-04-07, released 2004-06-03
The last revision prior to the SCOP 1.75 freeze date was dated 2004-07-29, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.132
AEROSPACI score: 0.63 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 2-oxoisovalerate dehydrogenase alpha subunit
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1v16a_
  • Chain 'B':
    Compound: 2-oxoisovalerate dehydrogenase beta subunit
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1v16b1, d1v16b2
  • Heterogens: K, MN, CL, TDP, BEN, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1v16A (A:)
sslddkpqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlkl
yksmtllntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgqyreagvlm
yrdyplelfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakr
ananrvvicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgia
argpgygimsirvdgndvfavynatkearrravaenqpflieamtyrighastsddssaf
rsvdevnywdkqdhpisrlrhyllsqgwwdeeqekawrkqsrrkvmeafeqaerkpkpnp
nllfsdvyqempaqlrkqqeslarhlqtygehypldhfdk

    Sequence, based on observed residues (ATOM records): (download) 
    >1v16A (A:)
kpqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlklyksmt
llntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgqyreagvlmyrdyp
lelfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakrananr
vvicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgiaargpg
ygimsirvdgndvfavynatkearrravaenqpflieamtyridhpisrlrhyllsqgww
deeqekawrkqsrrkvmeafeqaerkpkpnpnllfsdvyqempaqlrkqqeslarhlqty
gehypldhfdk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1v16B (B:)
vahftfqpdpepreygqtqkmnlfqsvtsaldnslakdptavifgedvafggvfrctvgl
rdkygkdrvfntplceqgivgfgigiavtgataiaeiqfadyifpafdqivneaakyryr
sgdlfncgsltirspwgcvghgalyhsqspeaffahcpgikvviprspfqakglllscie
dknpciffepkilyraaaeevpiepyniplsqaeviqegsdvtlvawgtqvhvirevasm
akeklgvscevidlrtiipwdvdticksviktgrllisheapltggfaseisstvqeecf
lnleapisrvcgydtpfphifepfyipdkwkcydalrkminy

    Sequence, based on observed residues (ATOM records): (download) 
    >1v16B (B:)
ahftfqpeygqtqkmnlfqsvtsaldnslakdptavifgedvafggvfrctvglrdkygk
drvfntplceqgivgfgigiavtgataiaeiqfadyifpafdqivneaakyryrsgdlfn
cgsltirspwgcvghgalyhsqspeaffahcpgikvviprspfqakglllsciedknpci
ffepkilyraaaeevpiepyniplsqaeviqegsdvtlvawgtqvhvirevasmakeklg
vscevidlrtiipwdvdticksviktgrllisheapltggfaseisstvqeecflnleap
isrvcgydtpfphifepfyipdkwkcydalrkminy