PDB entry 1ump

View 1ump on RCSB PDB site
Description: geometry of triterpene conversion to pentacarbocyclic hopene
Class: isomerase
Keywords: isomerase, triterpene cyclase, cholesterol biosynthesis, oxidosqualene cyclase, monotopic membrane protein
Deposited on 2003-08-27, released 2004-02-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-11-20, with a file datestamp of 2013-11-15.
Experiment type: XRAY
Resolution: 2.13 Å
R-factor: 0.187
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: squalene--hopene cyclase
    Species: ALICYCLOBACILLUS ACIDOCALDARIUS [TaxId:405212]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1umpa1, d1umpa2
  • Chain 'B':
    Compound: squalene--hopene cyclase
    Species: ALICYCLOBACILLUS ACIDOCALDARIUS [TaxId:405212]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1umpb1, d1umpb2
  • Chain 'C':
    Compound: squalene--hopene cyclase
    Species: ALICYCLOBACILLUS ACIDOCALDARIUS [TaxId:405212]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1umpc1, d1umpc2
  • Heterogens: C8E, SQA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1umpA (A:)
    maeqlveapayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdr
    mekirryllheqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsq
    ggiessrvftrmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsiv
    msrqpvfplperarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraa
    eiraldwllerqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyg
    gwmfqasispvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkp
    ggfafqfdnvyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgay
    dvdntsdlpnhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqk
    pdgswfgrwgvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsy
    edpayagkgastpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtg
    fpgdfylgytmyrhvfptlalgrykqaierr
    

    Sequence, based on observed residues (ATOM records): (download)
    >1umpA (A:)
    ayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdrmekirryll
    heqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsqggiessrvf
    trmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsivmsrqpvfpl
    perarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraaeiraldwll
    erqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyggwmfqasis
    pvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkpggfafqfdn
    vyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgaydvdntsdlp
    nhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqkpdgswfgrw
    gvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsyedpayagkg
    astpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtgfpgdfylgy
    tmyrhvfptlalgrykqaie
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1umpB (B:)
    maeqlveapayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdr
    mekirryllheqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsq
    ggiessrvftrmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsiv
    msrqpvfplperarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraa
    eiraldwllerqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyg
    gwmfqasispvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkp
    ggfafqfdnvyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgay
    dvdntsdlpnhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqk
    pdgswfgrwgvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsy
    edpayagkgastpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtg
    fpgdfylgytmyrhvfptlalgrykqaierr
    

    Sequence, based on observed residues (ATOM records): (download)
    >1umpB (B:)
    ayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdrmekirryll
    heqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsqggiessrvf
    trmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsivmsrqpvfpl
    perarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraaeiraldwll
    erqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyggwmfqasis
    pvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkpggfafqfdn
    vyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgaydvdntsdlp
    nhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqkpdgswfgrw
    gvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsyedpayagkg
    astpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtgfpgdfylgy
    tmyrhvfptlalgrykqaie
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1umpC (C:)
    maeqlveapayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdr
    mekirryllheqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsq
    ggiessrvftrmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsiv
    msrqpvfplperarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraa
    eiraldwllerqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyg
    gwmfqasispvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkp
    ggfafqfdnvyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgay
    dvdntsdlpnhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqk
    pdgswfgrwgvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsy
    edpayagkgastpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtg
    fpgdfylgytmyrhvfptlalgrykqaierr
    

    Sequence, based on observed residues (ATOM records): (download)
    >1umpC (C:)
    ayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdrmekirryll
    heqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsqggiessrvf
    trmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsivmsrqpvfpl
    perarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraaeiraldwll
    erqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyggwmfqasis
    pvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkpggfafqfdn
    vyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgaydvdntsdlp
    nhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqkpdgswfgrw
    gvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsyedpayagkg
    astpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtgfpgdfylgy
    tmyrhvfptlalgrykqaie