PDB entry 1udu

View 1udu on RCSB PDB site
Description: Crystal structure of Human Phosphodiesterase 5 complexed with tadalafil(Cialis)
Class: hydrolase
Keywords: cGMP-specific phosphodiesterase 5, Tadalafil, selective inhibitor
Deposited on 2003-05-06, released 2004-05-11
The last revision prior to the SCOP 1.73 freeze date was dated 2004-05-11, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.83 Å
R-factor: 0.263
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cGMP-specific 3',5'-cyclic phosphodiesterase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1udua_
  • Chain 'B':
    Compound: cGMP-specific 3',5'-cyclic phosphodiesterase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1udub_
  • Heterogens: ZN, MG, CIA

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1uduA (A:)
    trelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlc
    rwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdld
    hrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlkii
    kqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqq
    riaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvs
    edcfplldgcrknrqkwqalaeqq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1uduA (A:)
    trelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlc
    rwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdld
    hrgvnnsyychsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailatdlal
    yikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelvateff
    dqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvsedcfplldgcr
    knrqkwqalaeqq
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1uduB (B:)
    trelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlc
    rwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdld
    hrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlkii
    kqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqq
    riaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvs
    edcfplldgcrknrqkwqalaeqq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1uduB (B:)
    trelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlc
    rwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdld
    hrgvnnsyychsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailatdlal
    yikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelvateff
    dqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvsedcfplldgcr
    knrqkwqalaeqq