PDB entry 1u71

View 1u71 on RCSB PDB site
Description: Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH
Class: oxidoreductase
Keywords: human DHFR L22R variant, OXIDOREDUCTASE
Deposited on 2004-08-02, released 2005-02-01
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.211
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: dihydrofolate reductase
  Species: Homo sapiens [TaxId:9606]
  Gene: Dhfr
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00374 (0-185)
    • engineered (21)
  Domains in SCOPe 2.07: d1u71a_
• Heterogens: SO4, MXA, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1u71A (A:)
  vgslncivavsqnmgigkngdrpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
  peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
  ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
  vyeknd