PDB entry 1u70

View 1u70 on RCSB PDB site
Description: Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase
Class: oxidoreductase
Keywords: variant DHFR mouse, human, OXIDOREDUCTASE
Deposited on 2004-08-02, released 2005-02-01
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.225
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: dihydrofolate reductase
  Species: Mus musculus [TaxId:10090]
  Gene: Dhfr
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00375 (0-185)
    • engineered (21)
  Domains in SCOPe 2.07: d1u70a_
• Heterogens: MTX, NDP, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1u70A (A:)
  vrplncivavsqnmgigkngdrpwpplrnefkyfqrmtttssvegkqnlvimgrktwfsi
  peknrplkdrinivlsrelkepprgahflakslddalrlieqpelaskvdmvwivggssv
  yqeamnqpghlrlfvtrimqefesdtffpeidlgkykllpeypgvlsevqeekgikykfe
  vyekkd