SCOPe 2.08: Structural Classification of Proteins

PDB entry 1u0w

View 1u0w on RCSB PDB site
Description: An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases: 18xCHS+resveratrol Structure
Class: transferase
Keywords: type III polyketide synthase, PKS, condensing enzyme, thiolase fold, alpha-beta-alpha-beta-alpha fold, aldol switch, catalytic triad, engineered resveratrol synthase, RS, STS, CHS, chalcone synthase, stilbene synthase, TRANSFERASE
Deposited on 2004-07-14, released 2004-10-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.203
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Chalcone synthase 2
Species: Medicago sativa [TaxId:3879]
Gene: CHS2
Database cross-references and differences (RAF-indexed):
- Uniprot P30074 (Start-392)
  - engineered (99)
  - engineered (101-103)
  - engineered (134)
  - engineered (136-138)
  - engineered (140)
  - engineered (160-163)
  - engineered (165)
  - engineered (271-273)
  - engineered (276)
Domains in SCOPe 2.08: d1u0wa1, d1u0wa2
Chain 'B':
Compound: Chalcone synthase 2
Species: Medicago sativa [TaxId:3879]
Gene: CHS2
Database cross-references and differences (RAF-indexed):
- Uniprot P30074 (Start-392)
  - engineered (99)
  - engineered (101-103)
  - engineered (134)
  - engineered (136-138)
  - engineered (140)
  - engineered (160-163)
  - engineered (165)
  - engineered (271-273)
  - engineered (276)
Domains in SCOPe 2.08: d1u0wb1, d1u0wb2
Chain 'C':
Compound: Chalcone synthase 2
Species: Medicago sativa [TaxId:3879]
Gene: CHS2
Database cross-references and differences (RAF-indexed):
- Uniprot P30074 (Start-392)
  - engineered (99)
  - engineered (101-103)
  - engineered (134)
  - engineered (136-138)
  - engineered (140)
  - engineered (160-163)
  - engineered (165)
  - engineered (271-273)
  - engineered (276)
Domains in SCOPe 2.08: d1u0wc1, d1u0wc2
Chain 'D':
Compound: Chalcone synthase 2
Species: Medicago sativa [TaxId:3879]
Gene: CHS2
Database cross-references and differences (RAF-indexed):
- Uniprot P30074 (Start-392)
  - engineered (99)
  - engineered (101-103)
  - engineered (134)
  - engineered (136-138)
  - engineered (140)
  - engineered (160-163)
  - engineered (165)
  - engineered (271-273)
  - engineered (276)
Domains in SCOPe 2.08: d1u0wd1, d1u0wd2
Heterogens: STL, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>1u0wA (A:)
gshgmvsvseirkaqraegpatilaigtanpancveqstypdfyfkitnsehktelkekf
qrmcdksmikrrymylteeilkenpnvceymapsldarqamlamevprlgkeaavkaike
wgqpkskithlivcstttpdlpgadyqltkllglrpyvkrvgvfqhgcfaggtvlrlakd
laennkgarvlvvcsevtavtfrgpsdthldslvgqalfgdgaaalivgsdpvpeiekpi
femvwtaqtiapdsegaidghlreagltfhlkgavpdivsknitkalveafeplgisdyn
sifwiahpggpaildqveqklalkpekmnatrevlseygnmssacvlfildemrkkstqn
glkttgeglewgvlfgfgpgltietvvlrsvai

Sequence, based on observed residues (ATOM records): (download)

>1u0wA (A:)
vsvseirkaqraegpatilaigtanpancveqstypdfyfkitnsehktelkekfqrmcd
ksmikrrymylteeilkenpnvceymapsldarqamlamevprlgkeaavkaikewgqpk
skithlivcstttpdlpgadyqltkllglrpyvkrvgvfqhgcfaggtvlrlakdlaenn
kgarvlvvcsevtavtfrgpsdthldslvgqalfgdgaaalivgsdpvpeiekpifemvw
taqtiapdsegaidghlreagltfhlkgavpdivsknitkalveafeplgisdynsifwi
ahpggpaildqveqklalkpekmnatrevlseygnmssacvlfildemrkkstqnglktt
geglewgvlfgfgpgltietvvlrsvai

Chain 'B':
Sequence, based on SEQRES records: (download)

>1u0wB (B:)
gshgmvsvseirkaqraegpatilaigtanpancveqstypdfyfkitnsehktelkekf
qrmcdksmikrrymylteeilkenpnvceymapsldarqamlamevprlgkeaavkaike
wgqpkskithlivcstttpdlpgadyqltkllglrpyvkrvgvfqhgcfaggtvlrlakd
laennkgarvlvvcsevtavtfrgpsdthldslvgqalfgdgaaalivgsdpvpeiekpi
femvwtaqtiapdsegaidghlreagltfhlkgavpdivsknitkalveafeplgisdyn
sifwiahpggpaildqveqklalkpekmnatrevlseygnmssacvlfildemrkkstqn
glkttgeglewgvlfgfgpgltietvvlrsvai

Sequence, based on observed residues (ATOM records): (download)

>1u0wB (B:)
vsvseirkaqraegpatilaigtanpancveqstypdfyfkitnsehktelkekfqrmcd
ksmikrrymylteeilkenpnvceymapsldarqamlamevprlgkeaavkaikewgqpk
skithlivcstttpdlpgadyqltkllglrpyvkrvgvfqhgcfaggtvlrlakdlaenn
kgarvlvvcsevtavtfrgpsdthldslvgqalfgdgaaalivgsdpvpeiekpifemvw
taqtiapdsegaidghlreagltfhlkgavpdivsknitkalveafeplgisdynsifwi
ahpggpaildqveqklalkpekmnatrevlseygnmssacvlfildemrkkstqnglktt
geglewgvlfgfgpgltietvvlrsvai

Chain 'C':
Sequence, based on SEQRES records: (download)

>1u0wC (C:)
gshgmvsvseirkaqraegpatilaigtanpancveqstypdfyfkitnsehktelkekf
qrmcdksmikrrymylteeilkenpnvceymapsldarqamlamevprlgkeaavkaike
wgqpkskithlivcstttpdlpgadyqltkllglrpyvkrvgvfqhgcfaggtvlrlakd
laennkgarvlvvcsevtavtfrgpsdthldslvgqalfgdgaaalivgsdpvpeiekpi
femvwtaqtiapdsegaidghlreagltfhlkgavpdivsknitkalveafeplgisdyn
sifwiahpggpaildqveqklalkpekmnatrevlseygnmssacvlfildemrkkstqn
glkttgeglewgvlfgfgpgltietvvlrsvai

Sequence, based on observed residues (ATOM records): (download)

>1u0wC (C:)
vsvseirkaqraegpatilaigtanpancveqstypdfyfkitnsehktelkekfqrmcd
ksmikrrymylteeilkenpnvceymapsldarqamlamevprlgkeaavkaikewgqpk
skithlivcstttpdlpgadyqltkllglrpyvkrvgvfqhgcfaggtvlrlakdlaenn
kgarvlvvcsevtavtfrgpsdthldslvgqalfgdgaaalivgsdpvpeiekpifemvw
taqtiapdsegaidghlreagltfhlkgavpdivsknitkalveafeplgisdynsifwi
ahpggpaildqveqklalkpekmnatrevlseygnmssacvlfildemrkkstqnglktt
geglewgvlfgfgpgltietvvlrsvai

Chain 'D':
Sequence, based on SEQRES records: (download)

>1u0wD (D:)
gshgmvsvseirkaqraegpatilaigtanpancveqstypdfyfkitnsehktelkekf
qrmcdksmikrrymylteeilkenpnvceymapsldarqamlamevprlgkeaavkaike
wgqpkskithlivcstttpdlpgadyqltkllglrpyvkrvgvfqhgcfaggtvlrlakd
laennkgarvlvvcsevtavtfrgpsdthldslvgqalfgdgaaalivgsdpvpeiekpi
femvwtaqtiapdsegaidghlreagltfhlkgavpdivsknitkalveafeplgisdyn
sifwiahpggpaildqveqklalkpekmnatrevlseygnmssacvlfildemrkkstqn
glkttgeglewgvlfgfgpgltietvvlrsvai

Sequence, based on observed residues (ATOM records): (download)

>1u0wD (D:)
vsvseirkaqraegpatilaigtanpancveqstypdfyfkitnsehktelkekfqrmcd
ksmikrrymylteeilkenpnvceymapsldarqamlamevprlgkeaavkaikewgqpk
skithlivcstttpdlpgadyqltkllglrpyvkrvgvfqhgcfaggtvlrlakdlaenn
kgarvlvvcsevtavtfrgpsdthldslvgqalfgdgaaalivgsdpvpeiekpifemvw
taqtiapdsegaidghlreagltfhlkgavpdivsknitkalveafeplgisdynsifwi
ahpggpaildqveqklalkpekmnatrevlseygnmssacvlfildemrkkstqnglktt
geglewgvlfgfgpgltietvvlrsvai