PDB entry 1tzh

View 1tzh on RCSB PDB site
Description: Crystal Structure of the Fab YADS1 Complexed with h-VEGF
Class: immune system
Keywords: phage display, antibody library, protein engineering, immune system
Deposited on 2004-07-09, released 2004-08-31
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.215
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fab YADS1 Light Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 1TZH (0-End)
    Domains in SCOPe 2.07: d1tzha1, d1tzha2
  • Chain 'B':
    Compound: Fab YADS1 Heavy Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 1TZH (0-End)
    Domains in SCOPe 2.07: d1tzhb1, d1tzhb2
  • Chain 'H':
    Compound: Fab YADS1 Heavy Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 1TZH (0-End)
    Domains in SCOPe 2.07: d1tzhh1, d1tzhh2
  • Chain 'L':
    Compound: Fab YADS1 Light Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 1TZH (0-End)
    Domains in SCOPe 2.07: d1tzhl1, d1tzhl2
  • Chain 'V':
    Compound: Vascular Endothelial Growth Factor A
    Species: Homo sapiens [TaxId:9606]
    Gene: VEGF, VEGFA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1tzhv_
  • Chain 'W':
    Compound: Vascular Endothelial Growth Factor A
    Species: Homo sapiens [TaxId:9606]
    Gene: VEGF, VEGFA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1tzhw_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1tzhA (A:)
    diqmtqspsslsasvgdrvtitcrasqasyssvawyqqkpgkapklliyaasylysgvps
    rfsgsgsgtdftltisslqpedfatyycqssaspatfgqgtkveikrtvaapsvfifpps
    deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl
    skadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >1tzhA (A:)
    diqmtqspsslsasvgdrvtitcrasqasyssvawyqqkpgkapklliyaasylysgvps
    rfsgsgsgtdftltisslqpedfatyycqssaspatfgqgtkveikrtvaapsvfifpps
    deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl
    skadyekhkvyacevthqglsspvtksfnr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1tzhB (B:)
    evqlvesggglvqpggslrlscaasgfdiydddihwvrqapgkglewvayiapsygytdy
    adsvkgrftisadtskntaylqmnslraedtavyycsrssdasysysamdywgqgtlvtv
    ssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlq
    ssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkth
    

    Sequence, based on observed residues (ATOM records): (download)
    >1tzhB (B:)
    evqlvesggglvqpggslrlscaasgfdiydddihwvrqapgkglewvayiapsygytdy
    adsvkgrftisadtskntaylqmnslraedtavyycsrssdasysysamdywgqgtlvtv
    ssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlq
    ssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >1tzhH (H:)
    evqlvesggglvqpggslrlscaasgfdiydddihwvrqapgkglewvayiapsygytdy
    adsvkgrftisadtskntaylqmnslraedtavyycsrssdasysysamdywgqgtlvtv
    ssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlq
    ssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkth
    

    Sequence, based on observed residues (ATOM records): (download)
    >1tzhH (H:)
    evqlvesggglvqpggslrlscaasgfdiydddihwvrqapgkglewvayiapsygytdy
    adsvkgrftisadtskntaylqmnslraedtavyycsrssdasysysamdywgqgtlvtv
    ssastkgpsvfplapssgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
    slssvvtvpssslgtqtyicnvnhkpsntkvdkkvep
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >1tzhL (L:)
    diqmtqspsslsasvgdrvtitcrasqasyssvawyqqkpgkapklliyaasylysgvps
    rfsgsgsgtdftltisslqpedfatyycqssaspatfgqgtkveikrtvaapsvfifpps
    deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl
    skadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >1tzhL (L:)
    diqmtqspsslsasvgdrvtitcrasqasyssvawyqqkpgkapklliyaasylysgvps
    rfsgsgsgtdftltisslqpedfatyycqssaspatfgqgtkveikrtvaapsvfifpps
    deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl
    skadyekhkvyacevthqglsspvtksfnr
    

  • Chain 'V':
    Sequence, based on SEQRES records: (download)
    >1tzhV (V:)
    gqnhhevvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndegle
    cvpteesnitmqimrikphqgqhigemsflqhnkcecrpkkd
    

    Sequence, based on observed residues (ATOM records): (download)
    >1tzhV (V:)
    vvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndeglecvptee
    snitmqimrikphqgqhigemsflqhnkcecrpk
    

  • Chain 'W':
    Sequence, based on SEQRES records: (download)
    >1tzhW (W:)
    gqnhhevvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndegle
    cvpteesnitmqimrikphqgqhigemsflqhnkcecrpkkd
    

    Sequence, based on observed residues (ATOM records): (download)
    >1tzhW (W:)
    vvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndeglecvptee
    snitmqimrikphqgqhigemsflqhnkcecrpk