PDB entry 1tvo

View 1tvo on RCSB PDB site
Description: The structure of ERK2 in complex with a small molecule inhibitor
Class: transferase
Keywords: kinase, protein-inhibitor complex, transferase
Deposited on 2004-06-30, released 2005-09-13
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.265
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1tvoa_
  • Heterogens: FRZ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1tvoA (A:)
maaaaaagagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfe
hqtycqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqh
lsndhicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdh
tgflteyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhi
lgilgspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphk
rieveqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgyrs
gdlgsdel

    Sequence, based on observed residues (ATOM records): (download) 
    >1tvoA (A:)
gagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqr
tlreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhic
yflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgfltey
vatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgsp
sqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqa
lahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpg