PDB entry 1tvk

View 1tvk on RCSB PDB site
Description: The binding mode of epothilone A on a,b-tubulin by electron crystallography
Class: cell cycle, structural protein
Keywords: epothilone; taxol; ligand interactions, CELL CYCLE, STRUCTURAL PROTEIN
Deposited on 2004-06-29, released 2004-09-14
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-19.
Experiment type: ELECTRONCRYSTALLOGRAPHY
Resolution: 2.89 Å
R-factor: 0.333
AEROSPACI score: 0.03 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tubulin alpha chain
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02550
      • conflict (264)
    Domains in SCOPe 2.03: d1tvka1, d1tvka2
  • Chain 'B':
    Compound: Tubulin beta chain
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1tvkb1, d1tvkb2
  • Heterogens: GDP, GTP, EP

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1tvkA (A:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgfsvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrligqivssita
slrfdgalnvdltefqtnlvpyprghfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrtiqfvdwcptgfkvginyepp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgvdsv

    Sequence, based on observed residues (ATOM records): (download) 
    >1tvkA (A:)
recisihvgqagvqignacwelyclehgiqpdghvpravfvdleptvidevrtgtyrqlf
hpeqlitgkedaannyarghytigkeiidlvldrirkladqctglqgfsvfhsfgggtgs
gftsllmerlsvdygkksklefsiypapqvstavvepynsiltthttlehsdcafmvdne
aiydicrrnldierptytnlnrligqivssitaslrfdgalnvdltefqtnlvpyprghf
platyapvisaekayheqlsvaeitnacfepanqmvkcdprhgkymaccllyrgdvvpkd
vnaaiatiktkrtiqfvdwcptgfkvginyepptvvpggdlakvqravcmlsnttaiaea
warldhkfdlmyakrafvhwyvgegmeegefsearedmaalekdyeevgvds

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1tvkB (B:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneaagnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdaknmm
aacdprhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqd

    Sequence, based on observed residues (ATOM records): (download) 
    >1tvkB (B:)
reivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneaagnkyvp
railvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvvr
kesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvve
pynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttclr
fpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdaknmma
acdprhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprgl
kmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvse
yqqyqd