PDB entry 1tvh

View 1tvh on RCSB PDB site
Description: Crystal structure of Modified Melanoma Antigen gp100(209-T2M) Bound to Human Class I MHC HLA-A2
Class: immune system
Keywords: Melanoma; X-ray; modified gp100 peptide; gp100(209-T2M) peptide; MHC; HLA-A2
Deposited on 2004-06-29, released 2005-04-19
The last revision prior to the SCOP 1.73 freeze date was dated 2005-04-19, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.188
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: HOMO SAPIENS
    Gene: HLA-A, HLAA
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1tvha1, d1tvha2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: HOMO SAPIENS
    Gene: B2M
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOP 1.73: d1tvhb1
  • Chain 'C':
    Compound: epitope of Melanocyte protein Pmel 17
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot P40967 (0-8)
      • engineered (1)
  • Chain 'D':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: HOMO SAPIENS
    Gene: HLA-A, HLAA
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1tvhd1, d1tvhd2
  • Chain 'E':
    Compound: Beta-2-microglobulin
    Species: HOMO SAPIENS
    Gene: B2M
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOP 1.73: d1tvhe1
  • Chain 'F':
    Compound: epitope of Melanocyte protein Pmel 17
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot P40967 (0-8)
      • engineered (1)
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1tvhA (A:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1tvhB (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1tvhD (D:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1tvhE (E:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'F':
    No sequence available.