PDB entry 1tt5

View 1tt5 on RCSB PDB site
Description: Structure of APPBP1-UBA3-Ubc12N26: a unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8
Class: cell cycle, ligase
Keywords: cell cycle, ligase
Deposited on 2004-06-21, released 2004-09-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.237
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: amyloid protein-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB NP_003896 (2-530)
    Domains in SCOPe 2.08: d1tt5a_
  • Chain 'B':
    Compound: ubiquitin-activating enzyme E1C isoform 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB NP_003959 (3-End)
      • cloning artifact (0-2)
    Domains in SCOPe 2.08: d1tt5b1, d1tt5b2
  • Chain 'C':
    Compound: amyloid protein-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB NP_003896 (Start-530)
    Domains in SCOPe 2.08: d1tt5c_
  • Chain 'D':
    Compound: ubiquitin-activating enzyme E1C isoform 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB NP_003959
    Domains in SCOPe 2.08: d1tt5d_
  • Chain 'E':
    Compound: Ubiquitin-conjugating enzyme E2 M
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2M, UBC12
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Ubiquitin-conjugating enzyme E2 M
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2M, UBC12
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1tt5A (A:)
gsmaqlgkllkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsft
iidgnqvsgedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndps
ffcrftvvvatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdn
aledlrldkpfpelrehfqsydldhmekkdhshtpwiviiakylaqwysetngripktyk
ekedfrdlirqgilkpedeenfeeaiknvntalnttqipssiedifnddrcinitkqtps
fwilaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvak
llqsigqapesisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdnei
vlylmlravdrfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkddyvhefc
rygaaephtiaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql

    Sequence, based on observed residues (ATOM records): (download) 
    >1tt5A (A:)
maqlgkllkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsftii
dgnqvsgedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndpsff
crftvvvatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdnal
edlrldkpfpelrehfqsyddhshtpwiviiakylaqwysetngripktykekedfrdli
rqgilkpedeenfeeaiknvntalnttqipssiedifnddrcinitkqtpsfwilaralk
efvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsigqap
esisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdneivlylmlrav
drfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkddyvhefcrygaaepht
iaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1tt5B (B:)
mkldwegrwnhvkkflersgpfthpdfepsteslqflldtckvlvigagglgcellknla
lsgfrqihvidmdtidvsnlnrqflfrpkdigrpkaevaaeflndrvpncnvvphfnkiq
dfndtfyrqfhiivcgldsiiarrwingmlisllnyedgvldpssivplidggtegfkgn
arvilpgmtaciectlelyppqvnfpmctiasmprlpehcieyvrmlqwpkeqpfgegvp
ldgddpehiqwifqkslerasqynirgvtyrltqgvvkriipavastnaviaavcatevf
kiatsayiplnnylvfndvdglytytfeaerkencpacsqlpqniqfspsaklqevldyl
tnsaslqmkspaitatlegknrtlylqsvtsieertrpnlsktlkelglvdgqelavadv
ttpqtvlfklhfts

    Sequence, based on observed residues (ATOM records): (download) 
    >1tt5B (B:)
mkldwegrwnhvkkflersgpfthpdfepsteslqflldtckvlvigagglgcellknla
lsgfrqihvidmdtidvsnlnrqflfrpkdigrpkaevaaeflndrvpncnvvphfnkiq
dfndtfyrqfhiivcgldsiiarrwingmlisllnyedgvldpssivplidggtegfkgn
arvilpgmtaciectlelyppqvnfpmctiasmprlpehcieyvrmlqwpkeqpfgegvp
ldgddpehiqwifqkslerasqynirgvtyrltqgvvkriipavastnaviaavcatevf
kiatsayiplnnylvfndvdglytytfeaerkencpacsqlpqniqflqevldyltnsas
lqmkspaitatnrtlylqsvtsieertrplskglvdgqelavadvttpqtvlfk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1tt5C (C:)
gsmaqlgkllkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsft
iidgnqvsgedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndps
ffcrftvvvatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdn
aledlrldkpfpelrehfqsydldhmekkdhshtpwiviiakylaqwysetngripktyk
ekedfrdlirqgilkpedeenfeeaiknvntalnttqipssiedifnddrcinitkqtps
fwilaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvak
llqsigqapesisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdnei
vlylmlravdrfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkddyvhefc
rygaaephtiaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql

    Sequence, based on observed residues (ATOM records): (download) 
    >1tt5C (C:)
llkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsftiidgnqvs
gedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndpsffcrftvv
vatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdnaledlrld
kpfpelrehfqsyhtpwiviiakylaqwysetngripktykekedfrdlirqgilkpede
enfeeaiknvntalnttqipssiedifnddrcinitkqtpsfwilaralkefvakegqgn
lpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsigqapesisekelkl
lcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdneivlylmlravdrfhkqqgry
pgvsnyqveedigklkscltgflqeyglsvmvkddyvhefcrygaaephtiaaflggaaa
qevikiitkqfvifnntyiysgmsqtsatfql

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1tt5D (D:)
mkldwegrwnhvkkflersgpfthpdfepsteslqflldtckvlvigagglgcellknla
lsgfrqihvidmdtidvsnlnrqflfrpkdigrpkaevaaeflndrvpncnvvphfnkiq
dfndtfyrqfhiivcgldsiiarrwingmlisllnyedgvldpssivplidggtegfkgn
arvilpgmtaciectlelyppqvnfpmctiasmprlpehcieyvrmlqwpkeqpfgegvp
ldgddpehiqwifqkslerasqynirgvtyrltqgvvkriipavastnaviaavcatevf
kiatsayiplnnylvfndvdglytytfeaerkencpacsqlpqniqfspsaklqevldyl
tnsaslqmkspaitatlegknrtlylqsvtsieertrpnlsktlkelglvdgqelavadv
ttpqtvlfklhfts

    Sequence, based on observed residues (ATOM records): (download) 
    >1tt5D (D:)
wnhvkkflersgpfthpdfepsteslqflldtckvlvigagglgcellknlalsgfrqih
vidmdtidvsnlnrqflfrpkdigrpkaevaaeflndrvpncnvvphfnkiqdfndtfyr
qfhiivcgldsiiarrwingmlisllnyedgvldpssivplidggtegfkgnarvilpgm
taciectlelyppqvnfpmctiasmprlpehcieyvrmlqwpkeqpfgegvpldgddpeh
iqwifqkslerasqynirgvtyrltqgvvkriipavastnaviaavcatevfkiatsayi
plnnylvfndvdglytytfeaerkencpacsqlpqniqlqevldyltnsaslqmkspait
atknrtlylqvtsieertrplavadvttpqtvlfk

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.