PDB entry 1tq7
View 1tq7 on RCSB PDB site
Description: Crystal structure of the anticoagulant thrombin mutant W215A/E217A bound to PPACK
Class: hydrolase/hydrolase inhibitor
Keywords: thrombin, anticoagulant, BLOOD CLOTTING, PPACK, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Deposited on
2004-06-16, released
2004-08-03
The last revision prior to the SCOPe 2.06 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-08.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.205
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Prothrombin
Species: Homo sapiens [TaxId:9606]
Gene: F2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d1tq7.1 - Chain 'B':
Compound: Prothrombin
Species: Homo sapiens [TaxId:9606]
Gene: F2
Database cross-references and differences (RAF-indexed):
- Uniprot P00734 (0-256)
- engineered (226)
- engineered (228)
Domains in SCOPe 2.06: d1tq7.1 - Heterogens: ZN, 0G6, NAG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>1tq7A (A:)
yqtffnprtfgsgeadcglrplfekksledkterellesyidgr
- Chain 'B':
Sequence, based on SEQRES records: (download)
>1tq7B (B:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivsagagcdrdgkygfy
thvfrlkkwiqkvidqf
Sequence, based on observed residues (ATOM records): (download)
>1tq7B (B:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketkgqpsvlqvvnlpiverpvckdstriritdnmf
cagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivsagagcdrdgkygfythvfrl
kkwiqkvidqf