PDB entry 1tnf

View 1tnf on RCSB PDB site
Description: the structure of tumor necrosis factor-alpha at 2.6 angstroms resolution. implications for receptor binding
Class: lymphokine
Keywords: lymphokine
Deposited on 1989-08-25, released 1990-01-15
The last revision prior to the SCOP 1.75 freeze date was dated 2003-04-01, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.23
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tumor necrosis factor-alpha
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01375 (Start-156)
      • conflict (44)
    Domains in SCOP 1.75: d1tnfa_
  • Chain 'B':
    Compound: tumor necrosis factor-alpha
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01375 (Start-156)
      • conflict (44)
    Domains in SCOP 1.75: d1tnfb_
  • Chain 'C':
    Compound: tumor necrosis factor-alpha
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01375 (Start-156)
      • conflict (44)
    Domains in SCOP 1.75: d1tnfc_

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1tnfA (A:)
vrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliys
qvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiyl
ggvfqlekgdrlsaeinrpdyllfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnfA (A:)
rtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfk
gqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfq
lekgdrlsaeinrpdyllfaesgqvyfgiial

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1tnfB (B:)
vrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliys
qvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiyl
ggvfqlekgdrlsaeinrpdyllfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnfB (B:)
rtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfk
gqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfq
lekgdrlsaeinrpdyllfaesgqvyfgiial

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1tnfC (C:)
vrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliys
qvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiyl
ggvfqlekgdrlsaeinrpdyllfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnfC (C:)
rtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfk
gqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfq
lekgdrlsaeinrpdyllfaesgqvyfgiial