PDB entry 1tnb

View 1tnb on RCSB PDB site
Description: Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a substrate KKSKTKCVIF Peptide Derived from TC21
Class: Transferase
Keywords: GGTase-I, geranylgeranyltransferase type-I, geranylgeranyl transferase, prenyltransferase, CaaX, TC21, Lipid modification, prenylation, substrate selectivity
Deposited on 2004-06-11, released 2004-11-02
The last revision prior to the SCOP 1.73 freeze date was dated 2004-11-02, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: 0.189
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: geranylgeranyltransferase type I alpha subunit
    Species: Rattus norvegicus
    Gene: Fnta
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1tnba_
  • Chain 'B':
    Compound: Geranylgeranyl transferase type I beta subunit
    Species: Rattus norvegicus
    Gene: PGGT1B
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1tnbb_
  • Chain 'C':
    Compound: geranylgeranyltransferase type I alpha subunit
    Species: Rattus norvegicus
    Gene: Fnta
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1tnbc_
  • Chain 'D':
    Compound: Geranylgeranyl transferase type I beta subunit
    Species: Rattus norvegicus
    Gene: PGGT1B
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1tnbd_
  • Chain 'E':
    Compound: geranylgeranyltransferase type I alpha subunit
    Species: Rattus norvegicus
    Gene: Fnta
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1tnbe_
  • Chain 'F':
    Compound: Geranylgeranyl transferase type I beta subunit
    Species: Rattus norvegicus
    Gene: PGGT1B
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1tnbf_
  • Chain 'G':
    Compound: geranylgeranyltransferase type I alpha subunit
    Species: Rattus norvegicus
    Gene: Fnta
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1tnbg_
  • Chain 'H':
    Compound: Geranylgeranyl transferase type I beta subunit
    Species: Rattus norvegicus
    Gene: PGGT1B
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1tnbh_
  • Chain 'I':
    Compound: geranylgeranyltransferase type I alpha subunit
    Species: Rattus norvegicus
    Gene: Fnta
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1tnbi_
  • Chain 'J':
    Compound: Geranylgeranyl transferase type I beta subunit
    Species: Rattus norvegicus
    Gene: PGGT1B
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1tnbj_
  • Chain 'K':
    Compound: geranylgeranyltransferase type I alpha subunit
    Species: Rattus norvegicus
    Gene: Fnta
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1tnbk_
  • Chain 'L':
    Compound: Geranylgeranyl transferase type I beta subunit
    Species: Rattus norvegicus
    Gene: PGGT1B
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1tnbl_
  • Chain 'M':
    Compound: Fusion protein
    Species: synthetic, synthetic
  • Chain 'N':
    Compound: Fusion protein
    Species: synthetic, synthetic
  • Chain 'O':
    Compound: Fusion protein
    Species: synthetic, synthetic
  • Chain 'P':
    Compound: Fusion protein
    Species: synthetic, synthetic
  • Chain 'Q':
    Compound: Fusion protein
    Species: synthetic, synthetic
  • Chain 'R':
    Compound: Fusion protein
    Species: synthetic, synthetic
  • Heterogens: ZN, CL, MES, MGM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1tnbA (A:)
maategvgesapggepgqpeqpppppppppaqqpqeeemaaeageaaaspmddgflslds
ptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderserafklt
rdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrvlvewlk
dpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnnsvwnqr
hfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypnllnqll
dlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirkeywryig
rslqskhsresdipasv

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnbA (A:)
flsldsptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderse
rafkltrdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrv
lvewlkdpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnn
svwnqrhfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypn
llnqlldlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirke
ywryigrslqskhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1tnbB (B:)
maateddrlagsgegerldflrdrhvrffqrclqvlperyssletsrltiaffalsgldm
ldsldvvnkddiiewiyslqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsg
hiamtytglscliilgddlsrvdkeaclaglralqledgsfcavpegsendmrfvycasc
icymlnnwsgmdmkkaisyirrsmsydnglaqgagleshggstfcgiaslclmgkleevf
sekelnrikrwcimrqqngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyils
tqdrlvggfakwpdshpdalhayfgicglslmeesgickvhpalnvstrtserlrdlhqs
wktkdskqcsdnvhiss

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnbB (B:)
ldflrdrhvrffqrclqvlperyssletsrltiaffalsgldmldsldvvnkddiiewiy
slqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsghiamtytglscliilgd
dlsrvdkeaclaglralqledgsfcavpegsendmrfvycascicymlnnwsgmdmkkai
syirrsmsydnglaqgagleshggstfcgiaslclmgkleevfsekelnrikrwcimrqq
ngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyilstqdrlvggfakwpdshp
dalhayfgicglslmeesgickvhpalnvstrtserlrdlhqswkt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1tnbC (C:)
maategvgesapggepgqpeqpppppppppaqqpqeeemaaeageaaaspmddgflslds
ptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderserafklt
rdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrvlvewlk
dpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnnsvwnqr
hfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypnllnqll
dlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirkeywryig
rslqskhsresdipasv

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnbC (C:)
flsldsptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderse
rafkltrdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrv
lvewlkdpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnn
svwnqrhfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypn
llnqlldlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirke
ywryigrslqskhs

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1tnbD (D:)
maateddrlagsgegerldflrdrhvrffqrclqvlperyssletsrltiaffalsgldm
ldsldvvnkddiiewiyslqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsg
hiamtytglscliilgddlsrvdkeaclaglralqledgsfcavpegsendmrfvycasc
icymlnnwsgmdmkkaisyirrsmsydnglaqgagleshggstfcgiaslclmgkleevf
sekelnrikrwcimrqqngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyils
tqdrlvggfakwpdshpdalhayfgicglslmeesgickvhpalnvstrtserlrdlhqs
wktkdskqcsdnvhiss

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnbD (D:)
ldflrdrhvrffqrclqvlperyssletsrltiaffalsgldmldsldvvnkddiiewiy
slqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsghiamtytglscliilgd
dlsrvdkeaclaglralqledgsfcavpegsendmrfvycascicymlnnwsgmdmkkai
syirrsmsydnglaqgagleshggstfcgiaslclmgkleevfsekelnrikrwcimrqq
ngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyilstqdrlvggfakwpdshp
dalhayfgicglslmeesgickvhpalnvstrtserlrdlhqswkt

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1tnbE (E:)
maategvgesapggepgqpeqpppppppppaqqpqeeemaaeageaaaspmddgflslds
ptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderserafklt
rdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrvlvewlk
dpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnnsvwnqr
hfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypnllnqll
dlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirkeywryig
rslqskhsresdipasv

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnbE (E:)
flsldsptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderse
rafkltrdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrv
lvewlkdpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnn
svwnqrhfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypn
llnqlldlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirke
ywryigrslqskhs

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1tnbF (F:)
maateddrlagsgegerldflrdrhvrffqrclqvlperyssletsrltiaffalsgldm
ldsldvvnkddiiewiyslqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsg
hiamtytglscliilgddlsrvdkeaclaglralqledgsfcavpegsendmrfvycasc
icymlnnwsgmdmkkaisyirrsmsydnglaqgagleshggstfcgiaslclmgkleevf
sekelnrikrwcimrqqngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyils
tqdrlvggfakwpdshpdalhayfgicglslmeesgickvhpalnvstrtserlrdlhqs
wktkdskqcsdnvhiss

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnbF (F:)
ldflrdrhvrffqrclqvlperyssletsrltiaffalsgldmldsldvvnkddiiewiy
slqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsghiamtytglscliilgd
dlsrvdkeaclaglralqledgsfcavpegsendmrfvycascicymlnnwsgmdmkkai
syirrsmsydnglaqgagleshggstfcgiaslclmgkleevfsekelnrikrwcimrqq
ngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyilstqdrlvggfakwpdshp
dalhayfgicglslmeesgickvhpalnvstrtserlrdlhqswkt

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1tnbG (G:)
maategvgesapggepgqpeqpppppppppaqqpqeeemaaeageaaaspmddgflslds
ptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderserafklt
rdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrvlvewlk
dpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnnsvwnqr
hfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypnllnqll
dlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirkeywryig
rslqskhsresdipasv

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnbG (G:)
flsldsptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderse
rafkltrdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrv
lvewlkdpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnn
svwnqrhfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypn
llnqlldlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirke
ywryigrslqskhs

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1tnbH (H:)
maateddrlagsgegerldflrdrhvrffqrclqvlperyssletsrltiaffalsgldm
ldsldvvnkddiiewiyslqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsg
hiamtytglscliilgddlsrvdkeaclaglralqledgsfcavpegsendmrfvycasc
icymlnnwsgmdmkkaisyirrsmsydnglaqgagleshggstfcgiaslclmgkleevf
sekelnrikrwcimrqqngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyils
tqdrlvggfakwpdshpdalhayfgicglslmeesgickvhpalnvstrtserlrdlhqs
wktkdskqcsdnvhiss

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnbH (H:)
ldflrdrhvrffqrclqvlperyssletsrltiaffalsgldmldsldvvnkddiiewiy
slqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsghiamtytglscliilgd
dlsrvdkeaclaglralqledgsfcavpegsendmrfvycascicymlnnwsgmdmkkai
syirrsmsydnglaqgagleshggstfcgiaslclmgkleevfsekelnrikrwcimrqq
ngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyilstqdrlvggfakwpdshp
dalhayfgicglslmeesgickvhpalnvstrtserlrdlhqswkt

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >1tnbI (I:)
maategvgesapggepgqpeqpppppppppaqqpqeeemaaeageaaaspmddgflslds
ptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderserafklt
rdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrvlvewlk
dpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnnsvwnqr
hfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypnllnqll
dlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirkeywryig
rslqskhsresdipasv

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnbI (I:)
flsldsptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderse
rafkltrdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrv
lvewlkdpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnn
svwnqrhfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypn
llnqlldlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirke
ywryigrslqskhs

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >1tnbJ (J:)
maateddrlagsgegerldflrdrhvrffqrclqvlperyssletsrltiaffalsgldm
ldsldvvnkddiiewiyslqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsg
hiamtytglscliilgddlsrvdkeaclaglralqledgsfcavpegsendmrfvycasc
icymlnnwsgmdmkkaisyirrsmsydnglaqgagleshggstfcgiaslclmgkleevf
sekelnrikrwcimrqqngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyils
tqdrlvggfakwpdshpdalhayfgicglslmeesgickvhpalnvstrtserlrdlhqs
wktkdskqcsdnvhiss

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnbJ (J:)
ldflrdrhvrffqrclqvlperyssletsrltiaffalsgldmldsldvvnkddiiewiy
slqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsghiamtytglscliilgd
dlsrvdkeaclaglralqledgsfcavpegsendmrfvycascicymlnnwsgmdmkkai
syirrsmsydnglaqgagleshggstfcgiaslclmgkleevfsekelnrikrwcimrqq
ngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyilstqdrlvggfakwpdshp
dalhayfgicglslmeesgickvhpalnvstrtserlrdlhqswkt

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >1tnbK (K:)
maategvgesapggepgqpeqpppppppppaqqpqeeemaaeageaaaspmddgflslds
ptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderserafklt
rdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrvlvewlk
dpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnnsvwnqr
hfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypnllnqll
dlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirkeywryig
rslqskhsresdipasv

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnbK (K:)
flsldsptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderse
rafkltrdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrv
lvewlkdpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnn
svwnqrhfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypn
llnqlldlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirke
ywryigrslqskhs

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >1tnbL (L:)
maateddrlagsgegerldflrdrhvrffqrclqvlperyssletsrltiaffalsgldm
ldsldvvnkddiiewiyslqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsg
hiamtytglscliilgddlsrvdkeaclaglralqledgsfcavpegsendmrfvycasc
icymlnnwsgmdmkkaisyirrsmsydnglaqgagleshggstfcgiaslclmgkleevf
sekelnrikrwcimrqqngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyils
tqdrlvggfakwpdshpdalhayfgicglslmeesgickvhpalnvstrtserlrdlhqs
wktkdskqcsdnvhiss

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnbL (L:)
ldflrdrhvrffqrclqvlperyssletsrltiaffalsgldmldsldvvnkddiiewiy
slqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsghiamtytglscliilgd
dlsrvdkeaclaglralqledgsfcavpegsendmrfvycascicymlnnwsgmdmkkai
syirrsmsydnglaqgagleshggstfcgiaslclmgkleevfsekelnrikrwcimrqq
ngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyilstqdrlvggfakwpdshp
dalhayfgicglslmeesgickvhpalnvstrtserlrdlhqswkt

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    No sequence available.

  • Chain 'O':
    No sequence available.

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.

  • Chain 'R':
    No sequence available.