PDB entry 1tmb

View 1tmb on RCSB PDB site
Description: molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide a
Class: HYDROLASE/hydrolase inhibitor
Keywords: SERINE PROTEINASE, HYDROLASE-hydrolase inhibitor complex
Deposited on 1993-05-27, released 1994-01-31
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-06-05, with a file datestamp of 2013-05-31.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.138
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: alpha-thrombin (large subunit)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1tmb.1
  • Chain 'I':
    Compound: hirugen
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: alpha-thrombin (small subunit)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1tmb.1
  • Chain 'T':
    Compound: cyclotheonamide A
    Species: Theonella sp. [TaxId:73791]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00471 (0-4)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1tmbH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >1tmbH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketgqpsvlqvvnlpiverpvckdstriritdnmfc
agykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlk
kwiqkvidqfge

  • Chain 'I':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >1tmbL (L:)
tfgsgeadcglrplfekksledkterellesyidgr

    Sequence, based on observed residues (ATOM records): (download) 
    >1tmbL (L:)
geadcglrplfekksledkterellesyi

  • Chain 'T':
    No sequence available.