PDB entry 1tlo

View 1tlo on RCSB PDB site
Description: High resolution crystal structure of calpain I protease core in complex with E64
Class: hydrolase
Keywords: covalently-linked inhibitor at the active site (cysteine 115) forms a thioester, hydrolase
Deposited on 2004-06-09, released 2004-11-02
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.238
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Calpain 1, large [catalytic] subunit
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Capn1, Cls1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1tloa_
  • Heterogens: CA, E64, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1tloA (A:)
mglgrhenaikylgqdyenlrarclqngvlfqddafppvshslgfkelgpnssktygikw
krptellsnpqfivdgatrtdicqgalgdcwllaaiasltlnetilhrvvpygqsfqegy
agifhfqlwqfgewvdvvvddllptkdgklvfvhsaqgnefwsallekayakvngsyeal
sggctseafedftggvtewydlqkapsdlyqiilkalergsllgcsinisdirdleaitf
knlvrghaysvtdakqvtyqgqrvnlirmrnpwgevewkgpwsdnsyewnkvdpyereql
rvkmedgefwmsfrdfireftkleicnltpdlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >1tloA (A:)
naikylgqdyenlrarclqngvlfqddafppvshslgfkelgpnssktygikwkrptell
snpqfivdgatrtdicqgalgdcwllaaiasltlnetilhrvvpygqsfqegyagifhfq
lwqfgewvdvvvddllptkdgklvfvhsaqgnefwsallekayakvngsyealsggctse
afedftggvtewydlqkapsdlyqiilkalergsllgcsinisdirdleaitfknlvrgh
aysvtdakqvtyqgqrvnlirmrnpwgevewkgpwsdnsyewnkvdpyereqlrvkmedg
efwmsfrdfireftkleicnlt