PDB entry 1tl9

View 1tl9 on RCSB PDB site
Description: High resolution crystal structure of calpain I protease core in complex with leupeptin
Class: hydrolase/hydrolase inhibitor
Keywords: Covalently-linked inhibitor at the active site cysteine forms a hemithioacetal, hydrolase, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Deposited on 2004-06-09, released 2004-11-02
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.217
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Calpain 1, large [catalytic] subunit
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Capn1, Cls1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1tl9a_
  • Chain 'B':
    Compound: leupeptin inhibitor
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00487 (Start-2)
  • Heterogens: CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1tl9A (A:)
mglgrhenaikylgqdyenlrarclqngvlfqddafppvshslgfkelgpnssktygikw
krptellsnpqfivdgatrtdicqgalgdcwllaaiasltlnetilhrvvpygqsfqegy
agifhfqlwqfgewvdvvvddllptkdgklvfvhsaqgnefwsallekayakvngsyeal
sggctseafedftggvtewydlqkapsdlyqiilkalergsllgcsinisdirdleaitf
knlvrghaysvtdakqvtyqgqrvnlirmrnpwgevewkgpwsdnsyewnkvdpyereql
rvkmedgefwmsfrdfireftkleicnltpdlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >1tl9A (A:)
naikylgqdyenlrarclqngvlfqddafppvshslgfkelgpnssktygikwkrptell
snpqfivdgatrtdicqgalgdcwllaaiasltlnetilhrvvpygqsfqegyagifhfq
lwqfgewvdvvvddllptkdgklvfvhsaqgnefwsallekayakvngsyealsggctse
afedftggvtewydlqkapsdlyqiilkalergsllgcsinisdirdleaitfknlvrgh
aysvtdakqvtyqgqrvnlirmrnpwgevewkgpwsdnsyewnkvdpyereqlrvkmedg
efwmsfrdfireftkleicnl

  • Chain 'B':
    No sequence available.