PDB entry 1tl9
View 1tl9 on RCSB PDB site
Description: High resolution crystal structure of calpain I protease core in complex with leupeptin
Class: hydrolase/hydrolase inhibitor
Keywords: Covalently-linked inhibitor at the active site cysteine forms a hemithioacetal, hydrolase, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Deposited on
2004-06-09, released
2004-11-02
The last revision prior to the SCOPe 2.03 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-08.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.217
AEROSPACI score: 0.46
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Calpain 1, large [catalytic] subunit
Species: Rattus norvegicus [TaxId:10116]
Gene: Capn1, Cls1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d1tl9a_ - Chain 'B':
Compound: leupeptin inhibitor
Database cross-references and differences (RAF-indexed):
- Heterogens: CA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1tl9A (A:)
mglgrhenaikylgqdyenlrarclqngvlfqddafppvshslgfkelgpnssktygikw
krptellsnpqfivdgatrtdicqgalgdcwllaaiasltlnetilhrvvpygqsfqegy
agifhfqlwqfgewvdvvvddllptkdgklvfvhsaqgnefwsallekayakvngsyeal
sggctseafedftggvtewydlqkapsdlyqiilkalergsllgcsinisdirdleaitf
knlvrghaysvtdakqvtyqgqrvnlirmrnpwgevewkgpwsdnsyewnkvdpyereql
rvkmedgefwmsfrdfireftkleicnltpdlehhhhhh
Sequence, based on observed residues (ATOM records): (download)
>1tl9A (A:)
naikylgqdyenlrarclqngvlfqddafppvshslgfkelgpnssktygikwkrptell
snpqfivdgatrtdicqgalgdcwllaaiasltlnetilhrvvpygqsfqegyagifhfq
lwqfgewvdvvvddllptkdgklvfvhsaqgnefwsallekayakvngsyealsggctse
afedftggvtewydlqkapsdlyqiilkalergsllgcsinisdirdleaitfknlvrgh
aysvtdakqvtyqgqrvnlirmrnpwgevewkgpwsdnsyewnkvdpyereqlrvkmedg
efwmsfrdfireftkleicnl
- Chain 'B':
No sequence available.