PDB entry 1tkt

View 1tkt on RCSB PDB site
Description: crystal structure of hiv-1 reverse transcriptase in complex with gw426318
Class: transferase
Keywords: hiv-1 reverse transcriptase, aids, nnrti, gw426318, drug design, transferase
Deposited on 2004-06-09, released 2004-12-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-31, with a file datestamp of 2018-01-26.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pol polyproteins [Reverse transcriptase], Chain A
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585
      • modified residue (279)
    Domains in SCOPe 2.08: d1tkta1, d1tkta2
  • Chain 'B':
    Compound: Pol polyproteins [Reverse transcriptase], Chain B
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1tktb1
  • Heterogens: PO4, MG, H12, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1tktA (A:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelq
aiylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahk
giggneqvdklvsagirkvl

    Sequence, based on observed residues (ATOM records): (download) 
    >1tktA (A:)
pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfai
wrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrkytaf
tipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvg
sdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekd
swtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreil
kepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlte
avqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqle
kepivgaetfyvdagyvtnrgrqkvvtltdttnqktelqaiylalqdsglevnivtdsqy
algiiqaqpdqseselvnqiieqlikkekvylawvp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1tktB (B:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyqlekepivgaetf

    Sequence, based on observed residues (ATOM records): (download) 
    >1tktB (B:)
tvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkk
dstkwrklvdfrelnkrtqdfwphpaglkkkksvtvldvgdayfsvpldedfrkytafti
psinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvgsd
leigqhrtkieelrqhllrwgppflwmgyelhpdkwtvqpivlpekdswtvndiqklvgk
lnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpsk
dliaeiqkqgqgqwtyqiyqepfknlktgkyartndvkqlteavqkittesiviwgktpk
fklpiqketwetwwteywqatwipewefvntpplvklwy