PDB entry 1thp

View 1thp on RCSB PDB site
Description: structure of human alpha-thrombin y225p mutant bound to d-phe-pro-arg-chloromethylketone
Class: hydrolase/hydrolase inhibitor
Keywords: serine protease, fprck, hydrolase-hydrolase inhibitor complex
Deposited on 1999-01-26, released 1999-03-03
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.198
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein (thrombin light chain)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1thp.1
  • Chain 'B':
    Compound: protein (thrombin heavy chain)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00734 (0-256)
      • mutation (236)
    Domains in SCOPe 2.06: d1thp.1
  • Heterogens: 0G6, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1thpA (A:)
tfgsgeadcglrplfekksledkterellesyidgr

    Sequence, based on observed residues (ATOM records): (download) 
    >1thpA (A:)
adcglrplfekksledkterellesyi

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1thpB (B:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkpgfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >1thpB (B:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlkegqpsvlqvvnlpiverpvckdstriritdnmfca
gykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkpgfythvfrlkk
wiqkvidqf