PDB entry 1tg6

View 1tg6 on RCSB PDB site
Description: Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP
Class: hydrolase
Keywords: mitochondrial ClpP, Clp/Hsp 100, ATP-dependent protease, HYDROLASE
Deposited on 2004-05-28, released 2005-03-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.224
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Putative ATP-dependent Clp protease proteolytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1tg6a1
  • Chain 'B':
    Compound: Putative ATP-dependent Clp protease proteolytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1tg6b_
  • Chain 'C':
    Compound: Putative ATP-dependent Clp protease proteolytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1tg6c_
  • Chain 'D':
    Compound: Putative ATP-dependent Clp protease proteolytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1tg6d_
  • Chain 'E':
    Compound: Putative ATP-dependent Clp protease proteolytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1tg6e_
  • Chain 'F':
    Compound: Putative ATP-dependent Clp protease proteolytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1tg6f_
  • Chain 'G':
    Compound: Putative ATP-dependent Clp protease proteolytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1tg6g_
  • Heterogens: DIO, EDO, FME, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1tg6A (A:)
mwpgilvggarvascrypalgprlaahfpaqrppqrtlqnglalqrclhatatralplip
ivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyin
spggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqp
sggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgi
ldkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >1tg6A (A:)
plipivvydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyinspggv
vtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpsggar
gqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvl
vhpp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1tg6B (B:)
mwpgilvggarvascrypalgprlaahfpaqrppqrtlqnglalqrclhatatralplip
ivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyin
spggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqp
sggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgi
ldkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >1tg6B (B:)
plipivvydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyinspggv
vtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpsggar
gqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvl
vhp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1tg6C (C:)
mwpgilvggarvascrypalgprlaahfpaqrppqrtlqnglalqrclhatatralplip
ivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyin
spggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqp
sggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgi
ldkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >1tg6C (C:)
plipivvydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyinspggv
vtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpsggar
gqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvl
vhp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1tg6D (D:)
mwpgilvggarvascrypalgprlaahfpaqrppqrtlqnglalqrclhatatralplip
ivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyin
spggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqp
sggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgi
ldkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >1tg6D (D:)
plipivvydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyinspggv
vtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpsggar
gqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvl
vhpp

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1tg6E (E:)
mwpgilvggarvascrypalgprlaahfpaqrppqrtlqnglalqrclhatatralplip
ivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyin
spggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqp
sggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgi
ldkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >1tg6E (E:)
plipivvydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyinspggv
vtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpsggar
gqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvl
vhppqdgedeptlvqk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1tg6F (F:)
mwpgilvggarvascrypalgprlaahfpaqrppqrtlqnglalqrclhatatralplip
ivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyin
spggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqp
sggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgi
ldkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >1tg6F (F:)
plipivvydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyinspggv
vtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpsggar
gqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvl
vhppqdg

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1tg6G (G:)
mwpgilvggarvascrypalgprlaahfpaqrppqrtlqnglalqrclhatatralplip
ivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyin
spggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqp
sggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgi
ldkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >1tg6G (G:)
plipivvydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyinspggv
vtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpsggar
gqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvl
vhppqdgedeptlv