PDB entry 1tcx

View 1tcx on RCSB PDB site
Description: hiv triple mutant protease complexed with inhibitor sb203386
Class: hydrolase (acid protease)
Keywords: aids, polyprotein, hydrolase, aspartyl protease, endonuclease, RNA-directed DNA polymerase, acid protease, hydrolase (acid protease)
Deposited on 1996-06-05, released 1996-12-07
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.18
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: hiv protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: HIV-1 PROTEASE
  Database cross-references and differences (RAF-indexed):
  • Uniprot P04587 (0-98)
    • engineered (31)
    • engineered (46)
    • engineered (81)
  Domains in SCOPe 2.01: d1tcxa_
• Chain 'B':
  Compound: hiv protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: HIV-1 PROTEASE
  Database cross-references and differences (RAF-indexed):
  • Uniprot P04587 (0-98)
    • engineered (31)
    • engineered (46)
    • engineered (81)
  Domains in SCOPe 2.01: d1tcxb_
• Heterogens: IM1, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1tcxA (A:)
  pqitlwqrplvtikiggqlkealldtgaddtileemslpgrwkpkmvggiggfikvrqyd
  qilieicghkaigtvlvgptpiniigrnlltqigctlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1tcxB (B:)
  pqitlwqrplvtikiggqlkealldtgaddtileemslpgrwkpkmvggiggfikvrqyd
  qilieicghkaigtvlvgptpiniigrnlltqigctlnf