PDB entry 1tco

View 1tco on RCSB PDB site
Description: ternary complex of a calcineurin a fragment, calcineurin b, fkbp12 and the immunosuppressant drug fk506 (tacrolimus)
Deposited on 1996-08-21, released 1997-02-12
The last revision prior to the SCOP 1.71 freeze date was dated 1997-02-12, with a file datestamp of 1997-02-13.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.195
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Domains in SCOP 1.71: d1tcoa_
  • Chain 'B':
    Domains in SCOP 1.71: d1tcob_
  • Chain 'C':
    Domains in SCOP 1.71: d1tcoc_

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1tcoA (A:)
vkavpfppshrltakevfdndgkprvdilkahlmkegrleetvalriitegasilrqekn
lldidapvtvcgdihgqffdlmklfevggspantrylflgdyvdrgyfsiecvlylwalk
ilypktlfllrgnhecrhlteyftfkqeckikyservydacmdafdclplaalmnqqflc
vhgglspeintlddirkldrfkeppaygpmcdilwsdpledfgnektqehfthntvrgcs
yfysypavceflqhnnllsilraheaqdagyrmyrksqttgfpslitifsapnyldvynn
kaavlkyennvmnirqfncsphpywlpnfmdvftwslpfvgekvtemlvnvlnicsddel
gseedgfdgataaar

    Sequence, based on observed residues (ATOM records): (download) 
    >1tcoA (A:)
vpfppshrltakevfdndgkprvdilkahlmkegrleetvalriitegasilrqeknlld
idapvtvcgdihgqffdlmklfevggspantrylflgdyvdrgyfsiecvlylwalkily
pktlfllrgnhecrhlteyftfkqeckikyservydacmdafdclplaalmnqqflcvhg
glspeintlddirkldrfkeppaygpmcdilwsdpledfgnektqehfthntvrgcsyfy
sypavceflqhnnllsilraheaqdagyrmyrksqttgfpslitifsapnyldvynnkaa
vlkyennvmnirqfncsphpywlpnfmdvftwslpfvgekvtemlvnvlnic

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1tcoB (B:)
gneasyplemcshfdadeikrlgkrfkkldldnsgslsveefmslpelqqnplvqrvidi
fdtdgngevdfkefiegvsqfsvkgdkeqklrfafriydmdkdgyisngelfqvlkmmvg
nnlkdtqlqqivdktiinadkdgdgrisfeefcavvggldihkkmvvdv

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1tcoC (C:)
gvqvetispgdgrtfpkagqtcvvhytgmledgkkfdssrdrnkpfkfmlgkqevirgwe
egvaqmsvgqrakltispdyaygatghpgiipphatlvfdvellkle