PDB entry 1tc2

View 1tc2 on RCSB PDB site
Description: ternary substrate complex of the hypoxanthine phosphoribosyltransferase from trypanosoma cruzi
Class: transferase
Keywords: transferase, glycosyltransferase, phosphoribosyltransferase, nucleotide metabolism, purine salvage, ternary complex, near transition state
Deposited on 1998-11-04, released 2000-03-08
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.81 Å
R-factor: 0.183
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein (hypoxanthine phosphoribosyltransferase)
    Species: Trypanosoma cruzi [TaxId:5693]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q27796
      • variant (22)
      • variant (65)
      • variant (85)
    Domains in SCOPe 2.06: d1tc2a_
  • Chain 'B':
    Compound: protein (hypoxanthine phosphoribosyltransferase)
    Species: Trypanosoma cruzi [TaxId:5693]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q27796
      • variant (22)
      • variant (65)
      • variant (85)
    Domains in SCOPe 2.06: d1tc2b_
  • Heterogens: MG, MN, 7HP, PRP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1tc2A (A:)
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lcralcdfnvpvrmeficvssygegltssgqvrmlldtrhsieghhvlivedivdtaltl
nylyhmyftrrpaslktvvlldkregrrvpfsadyvvanipnafvigygldyddtyrelr
divvlrpevyaereaarqkkqraigsadtdrdakrefhsky

    Sequence, based on observed residues (ATOM records): (download) 
    >1tc2A (A:)
yefaekilfteeeirtrikevakriaddykgkglrpyvnplvlisvlkgsfmftadlcra
lcdfnvpvrmeficvssygegltssgqvrmlldtrhsieghhvlivedivdtaltlnyly
hmyftrrpaslktvvlldkregrrvpfsadyvvanipnafvigygldyddtyrelrdivv
lrpevy

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1tc2B (B:)
mpreyefaekilfteeeirtrikevakriaddykgkglrpyvnplvlisvlkgsfmftad
lcralcdfnvpvrmeficvssygegltssgqvrmlldtrhsieghhvlivedivdtaltl
nylyhmyftrrpaslktvvlldkregrrvpfsadyvvanipnafvigygldyddtyrelr
divvlrpevyaereaarqkkqraigsadtdrdakrefhsky

    Sequence, based on observed residues (ATOM records): (download) 
    >1tc2B (B:)
reyefaekilfteeeirtrikevakriaddykgkglrpyvnplvlisvlkgsfmftadlc
ralcdfnvpvrmeficvssygegltssgqvrmlldtrhsieghhvlivedivdtaltlny
lyhmyftrrpaslktvvlldkregrrvpfsadyvvanipnafvigygldyddtyrelrdi
vvlrpevyaereaarq