PDB entry 1t8l
View 1t8l on RCSB PDB site
Description: crystal structure of the p1 met bpti mutant- bovine chymotrypsin complex
Class: hydrolase/hydrolase inhibitor
Keywords: chymotrypsin; serine proteinase; bovine pancreatic trypsin inhibitor; bpti; protein-protein interaction; non-cognate binding; s1 pocket; primary specificity; crystal structure, hydrolase/hydrolase inhibitor complex
Deposited on
2004-05-13, released
2005-03-08
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.18
AEROSPACI score: 0.54
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Chymotrypsin A
Species: Bos taurus [TaxId:9913]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1t8la_ - Chain 'B':
Compound: pancreatic trypsin inhibitor
Species: Bos taurus [TaxId:9913]
Database cross-references and differences (RAF-indexed):
- Uniprot P00974 (1-58)
- initiating methionine (0)
- engineered (15)
- engineered (52)
Domains in SCOPe 2.08: d1t8lb_ - Chain 'C':
Compound: Chymotrypsin A
Species: Bos taurus [TaxId:9913]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1t8lc_ - Chain 'D':
Compound: pancreatic trypsin inhibitor
Species: Bos taurus [TaxId:9913]
Database cross-references and differences (RAF-indexed):
- Uniprot P00974 (1-58)
- initiating methionine (0)
- engineered (15)
- engineered (52)
Domains in SCOPe 2.08: d1t8ld_ - Heterogens: SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1t8lA (A:)
cgvpaiqpvlsglsrivngeeavpgswpwqvslqdktgfhfcggslinenwvvtaahcgv
ttsdvvvagefdqgsssekiqklkiakvfknskynsltinnditllklstaasfsqtvsa
vclpsasddfaagttcvttgwgltrytnantpdrlqqaslpllsntnckkywgtkikdam
icagasgvsscmgdsggplvckkngawtlvgivswgsstcststpgvyarvtalvnwvqq
tlaan
Sequence, based on observed residues (ATOM records): (download)
>1t8lA (A:)
cgvpaiqpvlsivngeeavpgswpwqvslqdktgfhfcggslinenwvvtaahcgvttsd
vvvagefdqgsssekiqklkiakvfknskynsltinnditllklstaasfsqtvsavclp
sasddfaagttcvttgwgltryantpdrlqqaslpllsntnckkywgtkikdamicagas
gvsscmgdsggplvckkngawtlvgivswgsstcststpgvyarvtalvnwvqqtlaan
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>1t8lB (B:)
mrpdfcleppytgpcmariiryfynakaglcqtfvyggcrakrnnfksaedclrtcgga
- Chain 'C':
Sequence, based on SEQRES records: (download)
>1t8lC (C:)
cgvpaiqpvlsglsrivngeeavpgswpwqvslqdktgfhfcggslinenwvvtaahcgv
ttsdvvvagefdqgsssekiqklkiakvfknskynsltinnditllklstaasfsqtvsa
vclpsasddfaagttcvttgwgltrytnantpdrlqqaslpllsntnckkywgtkikdam
icagasgvsscmgdsggplvckkngawtlvgivswgsstcststpgvyarvtalvnwvqq
tlaan
Sequence, based on observed residues (ATOM records): (download)
>1t8lC (C:)
cgvpaiqpvlsivngeeavpgswpwqvslqdktgfhfcggslinenwvvtaahcgvttsd
vvvagefdqgsssekiqklkiakvfknskynsltinnditllklstaasfsqtvsavclp
sasddfaagttcvttgwgltryantpdrlqqaslpllsntnckkywgtkikdamicagas
gvsscmgdsggplvckkngawtlvgivswgsstcststpgvyarvtalvnwvqqtlaan
- Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)
>1t8lD (D:)
mrpdfcleppytgpcmariiryfynakaglcqtfvyggcrakrnnfksaedclrtcgga