PDB entry 1t8a

View 1t8a on RCSB PDB site
Description: use of sequence duplication to engineer a ligand-triggered long-distance molecular switch in t4 lysosyme
Class: hydrolase
Keywords: molecular switch, t4 lysozyme, nano-bitechnology, protein engineering, protein design, hydrolase
Deposited on 2004-05-11, released 2004-08-17
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.218
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: lysozyme
  Species: Enterobacteria phage T4 [TaxId:10665]
  Gene: E
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00720 (0-174)
    • engineered (38)
    • insertion (39-49)
    • engineered (62)
    • engineered (64)
    • engineered (107)
  Domains in SCOPe 2.05: d1t8aa_
• Heterogens: CL, GAI, HED, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1t8aA (A:)
  mnifemlrideglrlkiykdtegyytigighlltkspsinaakseldkainaakseldka
  igantngvitkdeaeklfnqdvdaavrgilrnaklkpvydsldavrraalinmvfqmget
  gvagftnslrmlqqkrwdeaavnlaksrwynqtpnrakrvittfrtgtwdayknl