PDB entry 1t39

View 1t39 on RCSB PDB site
Description: human o6-alkylguanine-DNA alkyltransferase covalently crosslinked to DNA
Class: transferase/DNA
Keywords: alkyltransferase, methyltransferase, DNA repair, helix-turn-helix, transferase/DNA complex
Deposited on 2004-04-25, released 2004-07-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 3.3 Å
R-factor: 0.296
AEROSPACI score: 0.08 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: methylated-DNA--protein-cysteine methyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: MGMT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1t39a1, d1t39a2
  • Chain 'B':
    Compound: methylated-DNA--protein-cysteine methyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: MGMT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1t39b1, d1t39b2
  • Chain 'C':
    Compound: 5'-d(*gp*cp*cp*ap*tp*gp*(e1x)p*cp*tp*ap*gp*tp*a)-3'
  • Chain 'D':
    Compound: 5'-d(*tp*ap*cp*tp*ap*gp*cp*cp*ap*tp*gp*gp*c)-3'
  • Chain 'E':
    Compound: 5'-d(*gp*cp*cp*ap*tp*gp*(e1x)p*cp*tp*ap*gp*tp*a)-3'
  • Chain 'F':
    Compound: 5'-d(*tp*ap*cp*tp*ap*gp*cp*cp*ap*tp*gp*gp*c)-3'

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1t39A (A:)
    mrgshhhhhhgsmdkdcemkrttldsplgklelsgceqglheikllgkgtsaadavevpa
    paavlggpeplmqctawlnayfhqpeaieefpvpalhhpvfqqesftrqvlwkllkvvkf
    gevisyqqlaalagnpkaaravggamrgnpvpilipchrvvcssgavgnysgglavkewl
    laheghrl
    

    Sequence, based on observed residues (ATOM records): (download)
    >1t39A (A:)
    cemkrttldsplgklelsgceqglheikllgpeplmqctawlnayfhqpeaieefpvpal
    hhpvfqqesftrqvlwkllkvvkfgevisyqqlaalagnpkaaravggamrgnpvpilip
    chrvvcssgavgnysgglavkewllaheghr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1t39B (B:)
    mrgshhhhhhgsmdkdcemkrttldsplgklelsgceqglheikllgkgtsaadavevpa
    paavlggpeplmqctawlnayfhqpeaieefpvpalhhpvfqqesftrqvlwkllkvvkf
    gevisyqqlaalagnpkaaravggamrgnpvpilipchrvvcssgavgnysgglavkewl
    laheghrl
    

    Sequence, based on observed residues (ATOM records): (download)
    >1t39B (B:)
    mkrttldsplgklelsgceqglheikllgpeplmqctawlnayfhqpeaieefpvpalhh
    pvfqqesftrqvlwkllkvvkfgevisyqqlaalagnpkaaravggamrgnpvpilipch
    rvvcssgavgnysgglavkewllahegh
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.