PDB entry 1stc

View 1stc on RCSB PDB site
Description: camp-dependent protein kinase, alpha-catalytic subunit in complex with staurosporine
Class: complex (transferase/inhibitor)
Keywords: protein kinase, staurosporine, camp, phosphorylation, complex (transferase/inhibitor), serine/threonine-protein kinase
Deposited on 1997-10-10, released 1998-02-25
The last revision prior to the SCOP 1.75 freeze date was dated 2003-04-01, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.208
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'E':
    Compound: cAMP-DEPENDENT PROTEIN KINASE
    Species: BOS TAURUS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00517 (Start-349)
      • modified residue (196)
      • modified residue (337)
    Domains in SCOP 1.75: d1stce_
  • Chain 'I':
    Compound: protein kinase inhibitor
    Database cross-references and differences (RAF-indexed):
  • Heterogens: STU, HOH

PDB Chain Sequences:

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1stcE (E:)
gnaaaakkgseqesvkeflakakedflkkwenpaqntahldqferiktlgtgsfgrvmlv
khmetgnhyamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvm
eyvpggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyi
qvtdfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffa
dqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfatt
dwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

    Sequence, based on observed residues (ATOM records): (download) 
    >1stcE (E:)
vkeflakakedflkkwenpaqntahldqferiktlgtgsfgrvmlvkhmetgnhyamkil
dkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvpggemfshlrr
igrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrvkgr
twtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivsgk
vrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkveapf
ipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

  • Chain 'I':
    No sequence available.