PDB entry 1sr5

View 1sr5 on RCSB PDB site
Description: antithrombin-anhydrothrombin-heparin ternary complex structure
Class: hydrolase/hydrolase inhibitor
Keywords: serine proteinase inhibitor, antithrombin activation by hep anhydrothrombin, protein-protein interactions
Deposited on 2004-03-22, released 2004-08-17
The last revision prior to the SCOP 1.73 freeze date was dated 2004-10-19, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.227
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: antithrombin-III
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1sr5a_
  • Chain 'B':
    Compound: Prothrombin
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1sr5.1
  • Chain 'C':
    Compound: Prothrombin
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1sr5.1
  • Heterogens: NAG, NT1, NT2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1sr5A (A:)
    hgspvdictakprdipmnpmciyrspekkatedegseqkipeatnrrvwelskansrfat
    tfyqhladskndndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqih
    fffaklncrlyrkankssklvsanrlfgdksltfnetyqdiselvygaklqpldfkenae
    qsraainkwvsnktegritdvipseaineltvlvlvntiyfkglwkskfspentrkelfy
    kadgescsasmmyqegkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekelt
    pevlqewldeleemmlvvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrd
    dlyvsdafhkaflevneegseaaastavviagrslnpnrvtfkanrpflvfirevplnti
    ifmgrvanpcvk
    

    Sequence, based on observed residues (ATOM records): (download)
    >1sr5A (A:)
    vdictakprdipmnpmciyrspqkipeatnrrvwelskansrfattfyqhladskndndn
    iflsplsistafamtklgacndtlqqlmevfkfdtisektsdqihfffaklncrlyrkan
    kssklvsanrlfgdksltfnetyqdiselvygaklqpldfkenaeqsraainkwvsnkte
    gritdvipseaineltvlvlvntiyfkglwkskfspentrkelfykadgescsasmmyqe
    gkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekeltpevlqewldeleemm
    lvvhmprfriedgfslkeqlqdmglvdlfspeksklpgiddlyvsdafhkaflevneega
    aastavviagrslnpnrvtfkanrpflvfirevplntiifmgrvanpcv
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1sr5B (B:)
    tfgsgeadcglrplfekksledkterellesyidgr
    

    Sequence, based on observed residues (ATOM records): (download)
    >1sr5B (B:)
    fgsgeadcglrplfekksledkterellesyi
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1sr5C (C:)
    ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
    vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
    pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
    itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
    thvfrlkkwiqkvidqfge
    

    Sequence, based on observed residues (ATOM records): (download)
    >1sr5C (C:)
    ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
    vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
    pdretaasllqagykgrvtgwgnlkegqpsvlqvvnlpiverpvckdstriritdnmfca
    gykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlkk
    wiqkvidq