PDB entry 1sc6

View 1sc6 on RCSB PDB site
Description: Crystal Structure of W139G D-3-Phosphoglycerate dehydrogenase complexed with NAD+
Class: oxidoreductase
Keywords: allosteric regulation phosphoglycerate dehydrogenase PGDH, OXIDOREDUCTASE
Deposited on 2004-02-11, released 2005-02-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.09 Å
R-factor: 0.22
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: D-3-phosphoglycerate dehydrogenase
    Species: Escherichia coli [TaxId:562]
    Gene: SERA, B2913, C3494, Z4251, ECS3784, SF2898, S3098
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A9T0 (0-403)
      • engineered (74)
      • engineered (76)
      • engineered (132)
      • modified residue (168)
      • modified residue (196)
      • modified residue (213-214)
      • modified residue (222)
      • engineered (243)
      • engineered (275)
      • modified residue (334)
      • modified residue (369)
      • modified residue (390)
    Domains in SCOPe 2.07: d1sc6a1, d1sc6a2, d1sc6a3
  • Chain 'B':
    Compound: D-3-phosphoglycerate dehydrogenase
    Species: Escherichia coli [TaxId:562]
    Gene: SERA, B2913, C3494, Z4251, ECS3784, SF2898, S3098
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A9T0 (0-403)
      • engineered (74)
      • engineered (76)
      • engineered (132)
      • modified residue (168)
      • modified residue (196)
      • modified residue (213-214)
      • modified residue (222)
      • engineered (243)
      • engineered (275)
      • modified residue (334)
      • modified residue (369)
      • modified residue (390)
    Domains in SCOPe 2.07: d1sc6b1, d1sc6b2, d1sc6b3
  • Chain 'C':
    Compound: D-3-phosphoglycerate dehydrogenase
    Species: Escherichia coli [TaxId:562]
    Gene: SERA, B2913, C3494, Z4251, ECS3784, SF2898, S3098
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A9T0 (Start-403)
      • engineered (74)
      • engineered (76)
      • engineered (132)
      • modified residue (168)
      • modified residue (196)
      • modified residue (213-214)
      • modified residue (222)
      • engineered (243)
      • engineered (275)
      • modified residue (334)
      • modified residue (369)
      • modified residue (390)
    Domains in SCOPe 2.07: d1sc6c1, d1sc6c2, d1sc6c3
  • Chain 'D':
    Compound: D-3-phosphoglycerate dehydrogenase
    Species: Escherichia coli [TaxId:562]
    Gene: SERA, B2913, C3494, Z4251, ECS3784, SF2898, S3098
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A9T0 (0-403)
      • engineered (74)
      • engineered (76)
      • engineered (132)
      • modified residue (168)
      • modified residue (196)
      • modified residue (213-214)
      • modified residue (222)
      • engineered (243)
      • engineered (275)
      • modified residue (334)
      • modified residue (369)
      • modified residue (390)
    Domains in SCOPe 2.07: d1sc6d1, d1sc6d2, d1sc6d3
  • Heterogens: NAD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1sc6A (A:)
ekdkikfllvegvhqkaleslraagytniefhkgalddeqlkesirdahfiglrsrthlt
edvinaaeklvaigafaigtnqvdldaaakrgipvfnapfsntrsvaelvigelllllrg
vpeanakahrgvgnklaagsfeargkklgiigyghigtqlgilaeslgmyvyfydienkl
plgnatqvqhlsdllnmsdvvslhvpenpstknmmgakeislmkpgsllinasrgtvvdi
paladalaskhlagaaidvfptepatnsdpftsplaefdnvlltphiggstqeaqenigl
evagklikysdngstlsavnfpevslplhggrrlmhihenrpgvltalnkifaeqgvnia
aqylqtsaqmgyvvidieadedvaekalqamkaipgtirarlly

    Sequence, based on observed residues (ATOM records): (download) 
    >1sc6A (A:)
ekdkikfllvegvhqkaleslraagytniefhkgalddeqlkesirdahfiglrsrthlt
edvinaaeklvaigafaigtnqvdldaaakrgipvfnapfsntrsvaelvigelllllrg
vpeanakahrgvgnsfeargkklgiigyghigtqlgilaeslgmyvyfydienklplgna
tqvqhlsdllnmsdvvslhvpenpstknmmgakeislmkpgsllinasrgtvvdipalad
alaskhlagaaidvdpftsplaefdnvlltphiggstqeaqeniglevagklikysdngs
tlsavnfpevslplhggrrlmhihenrpgvltalnkifaeqgvniaaqylqtsaqmgyvv
idieadedvaekalqamkaipgtirarlly

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1sc6B (B:)
ekdkikfllvegvhqkaleslraagytniefhkgalddeqlkesirdahfiglrsrthlt
edvinaaeklvaigafaigtnqvdldaaakrgipvfnapfsntrsvaelvigelllllrg
vpeanakahrgvgnklaagsfeargkklgiigyghigtqlgilaeslgmyvyfydienkl
plgnatqvqhlsdllnmsdvvslhvpenpstknmmgakeislmkpgsllinasrgtvvdi
paladalaskhlagaaidvfptepatnsdpftsplaefdnvlltphiggstqeaqenigl
evagklikysdngstlsavnfpevslplhggrrlmhihenrpgvltalnkifaeqgvnia
aqylqtsaqmgyvvidieadedvaekalqamkaipgtirarlly

    Sequence, based on observed residues (ATOM records): (download) 
    >1sc6B (B:)
ekdkikfllvegvhqkaleslraagytniefhkgalddeqlkesirdahfiglrsrthlt
edvinaaeklvaigafaigtnqvdldaaakrgipvfnapfsntrsvaelvigelllllrg
vpeanakahrgvgnsfeargkklgiigyghigtqlgilaeslgmyvyfydienklplgna
tqvqhlsdllnmsdvvslhvpenpstknmmgakeislmkpgsllinasrgtvvdipalad
alaskhlagaaidsplaefdnvlltphiggstqeaqeniglevagklikysdngstlsav
nfpevslplhggrrlmhihenrpgvltalnkifaeqgvniaaqylqtsaqmgyvvidiea
dedvaekalqamkaipgtirarlly

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1sc6C (C:)
ekdkikfllvegvhqkaleslraagytniefhkgalddeqlkesirdahfiglrsrthlt
edvinaaeklvaigafaigtnqvdldaaakrgipvfnapfsntrsvaelvigelllllrg
vpeanakahrgvgnklaagsfeargkklgiigyghigtqlgilaeslgmyvyfydienkl
plgnatqvqhlsdllnmsdvvslhvpenpstknmmgakeislmkpgsllinasrgtvvdi
paladalaskhlagaaidvfptepatnsdpftsplaefdnvlltphiggstqeaqenigl
evagklikysdngstlsavnfpevslplhggrrlmhihenrpgvltalnkifaeqgvnia
aqylqtsaqmgyvvidieadedvaekalqamkaipgtirarlly

    Sequence, based on observed residues (ATOM records): (download) 
    >1sc6C (C:)
dkikfllvegvhqkaleslraagytniefhkgalddeqlkesirdahfiglrsrthlted
vinaaeklvaigafaigtnqvdldaaakrgipvfnapfsntrsvaelvigelllllrgvp
eanakahrgvgngsfeargkklgiigyghigtqlgilaeslgmyvyfydienklplgnat
qvqhlsdllnmsdvvslhvpenpstknmmgakeislmkpgsllinasrgtvvdipalada
laskhlagaaidvsplaefdnvlltpeaqeniglevagklikysdngstlsavnfpevsl
plhggrrlmhihenrpgvltalnkifaeqgvniaaqylqtsaqmgyvvidieadedvaek
alqamkaipgtirarlly

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1sc6D (D:)
ekdkikfllvegvhqkaleslraagytniefhkgalddeqlkesirdahfiglrsrthlt
edvinaaeklvaigafaigtnqvdldaaakrgipvfnapfsntrsvaelvigelllllrg
vpeanakahrgvgnklaagsfeargkklgiigyghigtqlgilaeslgmyvyfydienkl
plgnatqvqhlsdllnmsdvvslhvpenpstknmmgakeislmkpgsllinasrgtvvdi
paladalaskhlagaaidvfptepatnsdpftsplaefdnvlltphiggstqeaqenigl
evagklikysdngstlsavnfpevslplhggrrlmhihenrpgvltalnkifaeqgvnia
aqylqtsaqmgyvvidieadedvaekalqamkaipgtirarlly

    Sequence, based on observed residues (ATOM records): (download) 
    >1sc6D (D:)
ekdkikfllvegvhqkaleslraagytniefhkgalddeqlkesirdahfiglrsrthlt
edvinaaeklvaigafaigtnqvdldaaakrgipvfnapfsntrsvaelvigelllllrg
vpeanakahrgvgsfeargkklgiigyghigtqlgilaeslgmyvyfydienklplgnat
qvqhlsdllnmsdvvslhvpenpstknmmgakeislmkpgsllinasrgtvvdipalada
laskhlagaaidvpftsplaefdnvlltpstqeaqeniglevagklikysdngstlsavn
fpevslplhggrrlmhihenrpgvltalnkifaeqgvniaaqylqtsaqmgyvvidiead
edvaekalqamkaipgtirarlly