PDB entry 1sc4

View 1sc4 on RCSB PDB site
Description: Crystal structure of the human caspase-1 C285A mutant after removal of malonate
Class: hydrolase
Keywords: caspase-1 after removal of malonate, HYDROLASE
Deposited on 2004-02-11, released 2004-08-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.223
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Interleukin-1 beta convertase
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP1, IL1BC, IL1BCE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P29466 (Start-177)
      • engineered (165)
    Domains in SCOPe 2.08: d1sc4.1
  • Chain 'B':
    Compound: Interleukin-1 beta convertase
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP1, IL1BC, IL1BCE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1sc4.1
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1sc4A (A:)
    npamptssgsegnvklcsleeaqriwkqksaeiypimdkssrtrlaliicneefdsiprr
    tgaevditgmtmllqnlgysvdvkknltasdmtteleafahrpehktsdstflvfmshgi
    regicgkkhseqvpdilqlnaifnmlntkncpslkdkpkviiiqaargdspgvvwfkd
    

    Sequence, based on observed residues (ATOM records): (download)
    >1sc4A (A:)
    nvklcsleeaqriwkqksaeiypimdkssrtrlaliicneefdsiprrtgaevditgmtm
    llqnlgysvdvkknltasdmtteleafahrpehktsdstflvfmshgiregicgkkhseq
    vpdilqlnaifnmlntkncpslkdkpkviiiqaargdspgvvwfkd
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1sc4B (B:)
    aikkahiekdfiafcsstpdnvswrhptmgsvfigrliehmqeyacscdveeifrkvrfs
    feqpdgraqmpttervtltrcfylfpgh
    

    Sequence, based on observed residues (ATOM records): (download)
    >1sc4B (B:)
    aikkahiekdfiafcsstpdngsvfigrliehmqeyacscdveeifrkvrfsfeqpdgra
    qmpttervtltrcfylfpgh