PDB entry 1sc1

View 1sc1 on RCSB PDB site
Description: Crystal structure of an active-site ligand-free form of the human caspase-1 C285A mutant
Class: hydrolase
Keywords: ligand-free caspase-1, HYDROLASE
Deposited on 2004-02-11, released 2004-08-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-02-12, with a file datestamp of 2020-02-07.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Interleukin-1 beta convertase
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP1, IL1BC, IL1BCE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P29466 (Start-177)
      • engineered (165)
    Domains in SCOPe 2.08: d1sc1.1
  • Chain 'B':
    Compound: Interleukin-1 beta convertase
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP1, IL1BC, IL1BCE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1sc1.1
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1sc1A (A:)
npamptssgsegnvklcsleeaqriwkqksaeiypimdkssrtrlaliicneefdsiprr
tgaevditgmtmllqnlgysvdvkknltasdmtteleafahrpehktsdstflvfmshgi
regicgkkhseqvpdilqlnaifnmlntkncpslkdkpkviiiqaargdspgvvwfkd

    Sequence, based on observed residues (ATOM records): (download) 
    >1sc1A (A:)
gnvklcsleeaqriwkqksaeiypimdkssrtrlaliicneefdsiprrtgaevditgmt
mllqnlgysvdvkknltasdmtteleafahrpehktsdstflvfmshgiregicgkkhse
qvpdilqlnaifnmlntkncpslkdkpkviiiqaargdspgvvwfkd

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1sc1B (B:)
aikkahiekdfiafcsstpdnvswrhptmgsvfigrliehmqeyacscdveeifrkvrfs
feqpdgraqmpttervtltrcfylfpgh