PDB entry 1s9c

View 1s9c on RCSB PDB site
Description: Crystal structure analysis of the 2-enoyl-CoA hydratase 2 domain of human peroxisomal multifunctional enzyme type 2
Class: lyase
Keywords: hot-dog fold, hydratase 2 motif, multifunctional
Deposited on 2004-02-04, released 2005-02-15
The last revision prior to the SCOP 1.73 freeze date was dated 2005-02-15, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.229
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peroxisomal multifunctional enzyme type 2
    Species: HOMO SAPIENS
    Gene: HSD17B4, EDH17B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51659
      • engineered (241)
    Domains in SCOP 1.73: d1s9ca1, d1s9ca2
  • Chain 'B':
    Compound: Peroxisomal multifunctional enzyme type 2
    Species: HOMO SAPIENS
    Gene: HSD17B4, EDH17B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51659
      • engineered (241)
    Domains in SCOP 1.73: d1s9cb1, d1s9cb2
  • Chain 'C':
    Compound: Peroxisomal multifunctional enzyme type 2
    Species: HOMO SAPIENS
    Gene: HSD17B4, EDH17B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51659
      • engineered (241)
    Domains in SCOP 1.73: d1s9cc1, d1s9cc2
  • Chain 'D':
    Compound: Peroxisomal multifunctional enzyme type 2
    Species: HOMO SAPIENS
    Gene: HSD17B4, EDH17B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51659
      • engineered (241)
    Domains in SCOP 1.73: d1s9cd1, d1s9cd2
  • Chain 'E':
    Compound: Peroxisomal multifunctional enzyme type 2
    Species: HOMO SAPIENS
    Gene: HSD17B4, EDH17B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51659
      • engineered (241)
    Domains in SCOP 1.73: d1s9ce1, d1s9ce2
  • Chain 'F':
    Compound: Peroxisomal multifunctional enzyme type 2
    Species: HOMO SAPIENS
    Gene: HSD17B4, EDH17B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51659
      • engineered (241)
    Domains in SCOP 1.73: d1s9cf1, d1s9cf2
  • Chain 'G':
    Compound: Peroxisomal multifunctional enzyme type 2
    Species: HOMO SAPIENS
    Gene: HSD17B4, EDH17B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51659
      • engineered (241)
    Domains in SCOP 1.73: d1s9cg1, d1s9cg2
  • Chain 'H':
    Compound: Peroxisomal multifunctional enzyme type 2
    Species: HOMO SAPIENS
    Gene: HSD17B4, EDH17B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51659
      • engineered (241)
    Domains in SCOP 1.73: d1s9ch1, d1s9ch2
  • Chain 'I':
    Compound: Peroxisomal multifunctional enzyme type 2
    Species: HOMO SAPIENS
    Gene: HSD17B4, EDH17B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51659
      • engineered (241)
    Domains in SCOP 1.73: d1s9ci1, d1s9ci2
  • Chain 'J':
    Compound: Peroxisomal multifunctional enzyme type 2
    Species: HOMO SAPIENS
    Gene: HSD17B4, EDH17B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51659
      • engineered (241)
    Domains in SCOP 1.73: d1s9cj1, d1s9cj2
  • Chain 'K':
    Compound: Peroxisomal multifunctional enzyme type 2
    Species: HOMO SAPIENS
    Gene: HSD17B4, EDH17B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51659
      • engineered (241)
    Domains in SCOP 1.73: d1s9ck1, d1s9ck2
  • Chain 'L':
    Compound: Peroxisomal multifunctional enzyme type 2
    Species: HOMO SAPIENS
    Gene: HSD17B4, EDH17B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51659
      • engineered (241)
    Domains in SCOP 1.73: d1s9cl1, d1s9cl2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1s9cA (A:)
maatsgfagaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptf
gviigqksmmggglaeipglsinfakvlhgeqylelykplpragklkceavvadvldkgs
gvviimdvysysekelichnqfslflvgsggfggkrtsdkvkvavaipnrppdavltdtt
slnqaalyrlsgdwnplhidpnfaslagfdkpilhglctfgfsarrvlqqfadndvsrfk
avkarfakpvypgqtlqtemwkegnrihfqtkvqetgdivisnayvdlaptsgtsakl

    Sequence, based on observed residues (ATOM records): (download) 
    >1s9cA (A:)
aigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptfgviigqksm
mvlhgeqylelykplpragklkceavvadvlvviimdvysysekelichnqfslflsdkv
kvavaipnrppdavltdttslnqaalyrlsgdwnplhidpnfaslagfdkpilhglctfg
fsarrvlqqfadndvsrfkavkarfakpvypgqtlqtemwkegnrihfqtkvqetgdivi
snayvdla

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1s9cB (B:)
maatsgfagaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptf
gviigqksmmggglaeipglsinfakvlhgeqylelykplpragklkceavvadvldkgs
gvviimdvysysekelichnqfslflvgsggfggkrtsdkvkvavaipnrppdavltdtt
slnqaalyrlsgdwnplhidpnfaslagfdkpilhglctfgfsarrvlqqfadndvsrfk
avkarfakpvypgqtlqtemwkegnrihfqtkvqetgdivisnayvdlaptsgtsakl

    Sequence, based on observed residues (ATOM records): (download) 
    >1s9cB (B:)
gqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptfgviigqksinf
akvlhgeqylelykplpragklkceavvadvvviimdvysyselichnqfslfsdkvkva
vaipnrppdavltdttslnqaalyrlsgdwnplhidpnfaslagfdkpilhglctfgfsa
rrvlqqfadndvsrfkavkarfakpvypgqtlqtemwkegnrihfqtkvqetgdivisna
yvdla

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1s9cC (C:)
maatsgfagaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptf
gviigqksmmggglaeipglsinfakvlhgeqylelykplpragklkceavvadvldkgs
gvviimdvysysekelichnqfslflvgsggfggkrtsdkvkvavaipnrppdavltdtt
slnqaalyrlsgdwnplhidpnfaslagfdkpilhglctfgfsarrvlqqfadndvsrfk
avkarfakpvypgqtlqtemwkegnrihfqtkvqetgdivisnayvdlaptsgtsakl

    Sequence, based on observed residues (ATOM records): (download) 
    >1s9cC (C:)
gfagaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptfgviig
qksmglaeipglsinfakvlhgeqylelykplpragklkceavvadvldkgsgvviimdv
ysyselichnqfslflkrtsdkvkvavaipnrppdavltdttslnqaalyrlsgdwnplh
idpnfaslagfdkpilhglctfgfsarrvlqqfadndvsrfkavkarfakpvypgqtlqt
emwkegnrihfqtkvqetgdivisnayvdla

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1s9cD (D:)
maatsgfagaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptf
gviigqksmmggglaeipglsinfakvlhgeqylelykplpragklkceavvadvldkgs
gvviimdvysysekelichnqfslflvgsggfggkrtsdkvkvavaipnrppdavltdtt
slnqaalyrlsgdwnplhidpnfaslagfdkpilhglctfgfsarrvlqqfadndvsrfk
avkarfakpvypgqtlqtemwkegnrihfqtkvqetgdivisnayvdlaptsgtsakl

    Sequence, based on observed residues (ATOM records): (download) 
    >1s9cD (D:)
gaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptfgviigqks
mmlaeipnfakvlhgeqylelykplpragklkceavvadvlvviimdvysysekelichn
qfslflkrtsdkvkvavaipnrppdavltdttslnqaalyrlsgdwnplhidpnfaslag
fdkpilhglctfgfsarrvlqqfadndvsrfkavkarfakpvypgqtlqtemwkegnrih
fqtkvqetgdivisnayvdla

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1s9cE (E:)
maatsgfagaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptf
gviigqksmmggglaeipglsinfakvlhgeqylelykplpragklkceavvadvldkgs
gvviimdvysysekelichnqfslflvgsggfggkrtsdkvkvavaipnrppdavltdtt
slnqaalyrlsgdwnplhidpnfaslagfdkpilhglctfgfsarrvlqqfadndvsrfk
avkarfakpvypgqtlqtemwkegnrihfqtkvqetgdivisnayvdlaptsgtsakl

    Sequence, based on observed residues (ATOM records): (download) 
    >1s9cE (E:)
gqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptfgviigqksvlh
geqylelykplpragklkceavvadvlviimdvysysekelichnqfslflsdkvkvava
ipnrppdavltdttslnqaalyrlsgdwnplhidpnfaslagfdkpilhglctfgfsarr
vlqqfadndvsrfkavkarfakpvypgqtlqtemwkegnrihfqtkvqetgdivisnayv
dla

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1s9cF (F:)
maatsgfagaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptf
gviigqksmmggglaeipglsinfakvlhgeqylelykplpragklkceavvadvldkgs
gvviimdvysysekelichnqfslflvgsggfggkrtsdkvkvavaipnrppdavltdtt
slnqaalyrlsgdwnplhidpnfaslagfdkpilhglctfgfsarrvlqqfadndvsrfk
avkarfakpvypgqtlqtemwkegnrihfqtkvqetgdivisnayvdlaptsgtsakl

    Sequence, based on observed residues (ATOM records): (download) 
    >1s9cF (F:)
agaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptfgviigqk
smmggglainfakvlhgeqylelykplpragklkceavvadvldkgsgvviimdvysyse
kelichnqfslflvgsggfggkrtsdkvkvavaipnrppdavltdttslnqaalyrlsgd
wnplhidpnfaslagfdkpilhglctfgfsarrvlqqfadndvsrfkavkarfakpvypg
qtlqtemwkegnrihfqtkvqetgdivisnayvdla

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1s9cG (G:)
maatsgfagaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptf
gviigqksmmggglaeipglsinfakvlhgeqylelykplpragklkceavvadvldkgs
gvviimdvysysekelichnqfslflvgsggfggkrtsdkvkvavaipnrppdavltdtt
slnqaalyrlsgdwnplhidpnfaslagfdkpilhglctfgfsarrvlqqfadndvsrfk
avkarfakpvypgqtlqtemwkegnrihfqtkvqetgdivisnayvdlaptsgtsakl

    Sequence, based on observed residues (ATOM records): (download) 
    >1s9cG (G:)
gfagaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptfgviig
qksmmggglaeipglsinfakvlhgeqylelykplpragklkceavvadvldkgsgvvii
mdvysysekelichnqfslflvgsggfggkrtsdkvkvavaipnrppdavltdttslnqa
alyrlsgdwnplhidpnfaslagfdkpilhglctfgfsarrvlqqfadndvsrfkavkar
fakpvypgqtlqtemwkegnrihfqtkvqetgdivisnayvdla

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1s9cH (H:)
maatsgfagaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptf
gviigqksmmggglaeipglsinfakvlhgeqylelykplpragklkceavvadvldkgs
gvviimdvysysekelichnqfslflvgsggfggkrtsdkvkvavaipnrppdavltdtt
slnqaalyrlsgdwnplhidpnfaslagfdkpilhglctfgfsarrvlqqfadndvsrfk
avkarfakpvypgqtlqtemwkegnrihfqtkvqetgdivisnayvdlaptsgtsakl

    Sequence, based on observed residues (ATOM records): (download) 
    >1s9cH (H:)
gqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptfgviigqkvlhg
eqylelykplpragklkceavvadvldkgsgvviimdvysyselichnqfslflgkrtsd
kvkvavaipnrppdavltdttslnqaalyrlsgdwnplhidpnfaslagfdkpilhglct
fgfsarrvlqqfadndvsrfkavkarfakpvypgqtlqtemwkegnrihfqtkvqetgdi
visnayvdla

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >1s9cI (I:)
maatsgfagaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptf
gviigqksmmggglaeipglsinfakvlhgeqylelykplpragklkceavvadvldkgs
gvviimdvysysekelichnqfslflvgsggfggkrtsdkvkvavaipnrppdavltdtt
slnqaalyrlsgdwnplhidpnfaslagfdkpilhglctfgfsarrvlqqfadndvsrfk
avkarfakpvypgqtlqtemwkegnrihfqtkvqetgdivisnayvdlaptsgtsakl

    Sequence, based on observed residues (ATOM records): (download) 
    >1s9cI (I:)
fagaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptfgviigq
ksmmggglaeipglsinfakvlhgeqylelykplpragklkceavvadvldkgsgvviim
dvysysekelichnqfslflvgsggfggkrtsdkvkvavaipnrppdavltdttslnqaa
lyrlsgdwnplhidpnfaslagfdkpilhglctfgfsarrvlqqfadndvsrfkavkarf
akpvypgqtlqtemwkegnrihfqtkvqetgdivisnayvdla

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >1s9cJ (J:)
maatsgfagaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptf
gviigqksmmggglaeipglsinfakvlhgeqylelykplpragklkceavvadvldkgs
gvviimdvysysekelichnqfslflvgsggfggkrtsdkvkvavaipnrppdavltdtt
slnqaalyrlsgdwnplhidpnfaslagfdkpilhglctfgfsarrvlqqfadndvsrfk
avkarfakpvypgqtlqtemwkegnrihfqtkvqetgdivisnayvdlaptsgtsakl

    Sequence, based on observed residues (ATOM records): (download) 
    >1s9cJ (J:)
gqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptfgviigqksmmi
nfakvlhgeqylelykplpragklkceavvadvldkgvviimdvysyseelichnqfslf
lrtsdkvkvavaipnrppdavltdttslnqaalyrlsgdwnplhidpnfaslagfdkpil
hglctfgfsarrvlqqfadndvsrfkavkarfakpvypgqtlqtemwkegnrihfqtkvq
etgdivisnayvdla

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >1s9cK (K:)
maatsgfagaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptf
gviigqksmmggglaeipglsinfakvlhgeqylelykplpragklkceavvadvldkgs
gvviimdvysysekelichnqfslflvgsggfggkrtsdkvkvavaipnrppdavltdtt
slnqaalyrlsgdwnplhidpnfaslagfdkpilhglctfgfsarrvlqqfadndvsrfk
avkarfakpvypgqtlqtemwkegnrihfqtkvqetgdivisnayvdlaptsgtsakl

    Sequence, based on observed residues (ATOM records): (download) 
    >1s9cK (K:)
igqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptfgviigqksak
vlhgeqylelykplpragklkceavvadvldkgsgvviimdvysyselichnqfslflvg
skrtsdkvkvavaipnrppdavltdttslnqaalyrlsgdwnplhidpnfaslagfdkpi
lhglctfgfsarrvlqqfadndvsrfkavkarfakpvypgqtlqtemwkegnrihfqtkv
qetgdivisnayvdla

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >1s9cL (L:)
maatsgfagaigqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptf
gviigqksmmggglaeipglsinfakvlhgeqylelykplpragklkceavvadvldkgs
gvviimdvysysekelichnqfslflvgsggfggkrtsdkvkvavaipnrppdavltdtt
slnqaalyrlsgdwnplhidpnfaslagfdkpilhglctfgfsarrvlqqfadndvsrfk
avkarfakpvypgqtlqtemwkegnrihfqtkvqetgdivisnayvdlaptsgtsakl

    Sequence, based on observed residues (ATOM records): (download) 
    >1s9cL (L:)
gqklppfsyayteleaimyalgvgasikdpkdlkfiyegssdfsclptfgviigqksmmn
fakvlhgeqylelykplpragklkceavvadvldkgsgvviimdvysysekelichnqfs
lflvgsggfggkrtsdkvkvavaipnrppdavltdttslnqaalyrlsgdwnplhidppi
lhglctfgfsarrvlqqfadndvsrfkavkarfakpvypgqtlqtemwkegnrihfqtkv
qetgdivisnayvdla