PDB entry 1s78

View 1s78 on RCSB PDB site
Description: Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
Class: transferase
Keywords: receptor-antibody complex, Fab fragment, cysteine-rich domain, leucine-rich repeat, TRANSFERASE
Deposited on 2004-01-29, released 2004-04-27
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 3.25 Å
R-factor: 0.465
AEROSPACI score: -0.09 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Receptor protein-tyrosine kinase erbB-2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB2, HER2, NGL, NEU
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1s78a1, d1s78a2, d1s78a3, d1s78a4
  • Chain 'B':
    Compound: Receptor protein-tyrosine kinase erbB-2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB2, HER2, NGL, NEU
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1s78b1, d1s78b2, d1s78b3, d1s78b4
  • Chain 'C':
    Compound: Pertuzumab Fab light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 1S78 (0-213)
    Domains in SCOPe 2.05: d1s78c1, d1s78c2
  • Chain 'D':
    Compound: Pertuzumab Fab heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 1S78 (0-End)
    Domains in SCOPe 2.05: d1s78d1, d1s78d2
  • Chain 'E':
    Compound: Pertuzumab Fab light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 1S78 (0-213)
    Domains in SCOPe 2.05: d1s78e1, d1s78e2
  • Chain 'F':
    Compound: Pertuzumab Fab heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 1S78 (0-End)
    Domains in SCOPe 2.05: d1s78f1, d1s78f2
  • Heterogens: NAG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1s78A (A:)
    tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
    yvliahnqvrqvplqrlrivrgtqlfednyalavldngdplnnttpvtgaspgglrelql
    rslteilkggvliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgs
    rcwgessedcqsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsg
    icelhcpalvtyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqev
    taedgtqrcekcskpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfd
    gdpasntaplqpeqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngays
    ltlqglgiswlglrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrped
    ecvgeglachqlcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclp
    chpecqpqngsvtcfgpeadqcvacahykdppfcvarcpsgvkpdlsympiwkfpdeega
    cqpcpincthscvdlddkgcpaeq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1s78A (A:)
    tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
    yvliahnqvrqvplqrlrivrgtqlfednyalavldngdplspgglrelqlrslteilkg
    gvliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgsrcwgessed
    cqsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsgicelhcpal
    vtyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqevtaedgtqrc
    ekcskpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfdgdpasntap
    lqpeqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngaysltlqglgis
    wlglrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrpedecvgeglac
    hqlcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclpchpecqpqn
    gsvtcfgpeadqcva
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1s78B (B:)
    tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
    yvliahnqvrqvplqrlrivrgtqlfednyalavldngdplnnttpvtgaspgglrelql
    rslteilkggvliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgs
    rcwgessedcqsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsg
    icelhcpalvtyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqev
    taedgtqrcekcskpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfd
    gdpasntaplqpeqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngays
    ltlqglgiswlglrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrped
    ecvgeglachqlcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclp
    chpecqpqngsvtcfgpeadqcvacahykdppfcvarcpsgvkpdlsympiwkfpdeega
    cqpcpincthscvdlddkgcpaeq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1s78B (B:)
    tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
    yvliahnqvrqvplqrlrivrgtqlfednyalavldngdplspgglrelqlrslteilkg
    gvliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgsrcwgessed
    cqsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsgicelhcpal
    vtyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqevtaedgtqrc
    ekcskpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfdgdpasntap
    lqpeqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngaysltlqglgis
    wlglrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrpedecvgeglac
    hqlcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclpchpecqpqn
    gsvtcfgpeadqcvacahykdppfcvar
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1s78C (C:)
    diqmtqspsslsasvgdrvtitckasqdvsigvawyqqkpgkapklliysasyrytgvps
    rfsgsgsgtdftltisslqpedfatyycqqyyiypytfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >1s78D (D:)
    evqlvesggglvqpggslrlscaasgftftdytmdwvrqapgkglewvadvnpnsggsiy
    nqrfkgrftlsvdrskntlylqmnslraedtavyycarnlgpsfyfdywgqgtlvtvssa
    stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
    lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkth
    

    Sequence, based on observed residues (ATOM records): (download)
    >1s78D (D:)
    evqlvesggglvqpggslrlscaasgftftdytmdwvrqapgkglewvadvnpnsggsiy
    nqrfkgrftlsvdrskntlylqmnslraedtavyycarnlgpsfyfdywgqgtlvtvssa
    stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
    lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1s78E (E:)
    diqmtqspsslsasvgdrvtitckasqdvsigvawyqqkpgkapklliysasyrytgvps
    rfsgsgsgtdftltisslqpedfatyycqqyyiypytfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >1s78F (F:)
    evqlvesggglvqpggslrlscaasgftftdytmdwvrqapgkglewvadvnpnsggsiy
    nqrfkgrftlsvdrskntlylqmnslraedtavyycarnlgpsfyfdywgqgtlvtvssa
    stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
    lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkth
    

    Sequence, based on observed residues (ATOM records): (download)
    >1s78F (F:)
    evqlvesggglvqpggslrlscaasgftftdytmdwvrqapgkglewvadvnpnsggsiy
    nqrfkgrftlsvdrskntlylqmnslraedtavyycarnlgpsfyfdywgqgtlvtvssa
    stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
    lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc