PDB entry 1s78

View 1s78 on RCSB PDB site
Description: Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
Deposited on 2004-01-29, released 2004-04-27
The last revision prior to the SCOP 1.71 freeze date was dated 2004-04-27, with a file datestamp of 2004-04-27.
Experiment type: XRAY
Resolution: 3.25 Å
R-factor: 0.227
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1s78A (A:)
    tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
    yvliahnqvrqvplqrlrivrgtqlfednyalavldngdplnnttpvtgaspgglrelql
    rslteilkggvliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgs
    rcwgessedcqsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsg
    icelhcpalvtyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqev
    taedgtqrcekcskpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfd
    gdpasntaplqpeqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngays
    ltlqglgiswlglrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrped
    ecvgeglachqlcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclp
    chpecqpqngsvtcfgpeadqcvacahykdppfcvarcpsgvkpdlsympiwkfpdeega
    cqpcpincthscvdlddkgcpaeq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1s78A (A:)
    tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
    yvliahnqvrqvplqrlrivrgtqlfednyalavldngdplspgglrelqlrslteilkg
    gvliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgsrcwgessed
    cqsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsgicelhcpal
    vtyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqevtaedgtqrc
    ekcskpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfdgdpasntap
    lqpeqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngaysltlqglgis
    wlglrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrpedecvgeglac
    hqlcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclpchpecqpqn
    gsvtcfgpeadqcva
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1s78B (B:)
    tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
    yvliahnqvrqvplqrlrivrgtqlfednyalavldngdplnnttpvtgaspgglrelql
    rslteilkggvliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgs
    rcwgessedcqsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsg
    icelhcpalvtyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqev
    taedgtqrcekcskpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfd
    gdpasntaplqpeqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngays
    ltlqglgiswlglrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrped
    ecvgeglachqlcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclp
    chpecqpqngsvtcfgpeadqcvacahykdppfcvarcpsgvkpdlsympiwkfpdeega
    cqpcpincthscvdlddkgcpaeq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1s78B (B:)
    tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
    yvliahnqvrqvplqrlrivrgtqlfednyalavldngdplspgglrelqlrslteilkg
    gvliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgsrcwgessed
    cqsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsgicelhcpal
    vtyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqevtaedgtqrc
    ekcskpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfdgdpasntap
    lqpeqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngaysltlqglgis
    wlglrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrpedecvgeglac
    hqlcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclpchpecqpqn
    gsvtcfgpeadqcvacahykdppfcvar
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1s78C (C:)
    diqmtqspsslsasvgdrvtitckasqdvsigvawyqqkpgkapklliysasyrytgvps
    rfsgsgsgtdftltisslqpedfatyycqqyyiypytfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >1s78D (D:)
    evqlvesggglvqpggslrlscaasgftftdytmdwvrqapgkglewvadvnpnsggsiy
    nqrfkgrftlsvdrskntlylqmnslraedtavyycarnlgpsfyfdywgqgtlvtvssa
    stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
    lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkth
    

    Sequence, based on observed residues (ATOM records): (download)
    >1s78D (D:)
    evqlvesggglvqpggslrlscaasgftftdytmdwvrqapgkglewvadvnpnsggsiy
    nqrfkgrftlsvdrskntlylqmnslraedtavyycarnlgpsfyfdywgqgtlvtvssa
    stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
    lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1s78E (E:)
    diqmtqspsslsasvgdrvtitckasqdvsigvawyqqkpgkapklliysasyrytgvps
    rfsgsgsgtdftltisslqpedfatyycqqyyiypytfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >1s78F (F:)
    evqlvesggglvqpggslrlscaasgftftdytmdwvrqapgkglewvadvnpnsggsiy
    nqrfkgrftlsvdrskntlylqmnslraedtavyycarnlgpsfyfdywgqgtlvtvssa
    stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
    lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkth
    

    Sequence, based on observed residues (ATOM records): (download)
    >1s78F (F:)
    evqlvesggglvqpggslrlscaasgftftdytmdwvrqapgkglewvadvnpnsggsiy
    nqrfkgrftlsvdrskntlylqmnslraedtavyycarnlgpsfyfdywgqgtlvtvssa
    stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
    lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc