PDB entry 1s70

View 1s70 on RCSB PDB site
Description: Complex between protein ser/thr phosphatase-1 (delta) and the myosin phosphatase targeting subunit 1 (MYPT1)
Class: hydrolase
Keywords: myosin phosphatase, MYPT1, PP1, myosin regulation, deposphorylation, HYDROLASE
Deposited on 2004-01-28, released 2004-06-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.223
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine protein phosphatase PP1-beta (or delta) catalytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP1CB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62140 (3-End)
      • engineered (2)
    Domains in SCOPe 2.08: d1s70a_
  • Chain 'B':
    Compound: 130 kDa myosin-binding subunit of smooth muscle myosin phophatase (M130)
    Species: Gallus gallus [TaxId:9031]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1s70b_
  • Heterogens: MN, PGE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1s70A (A:)
aghmadgelnvdslitrllevrgcrpgkivqmteaevrglciksreiflsqpilleleap
lkicgdihgqytdllrlfeyggfppeanylflgdyvdrgkqsleticlllaykikypenf
fllrgnhecasinriygfydeckrrfniklwktftdcfnclpiaaivdekifcchgglsp
dlqsmeqirrimrptdvpdtgllcdllwsdpdkdvqgwgendrgvsftfgadvvskflnr
hdldlicrahqvvedgyeffakrqlvtlfsapnycgefdnaggmmsvdetlmcsfqilkp
sekkakyqygglnsgrpvtpprtanppkkr

    Sequence, based on observed residues (ATOM records): (download) 
    >1s70A (A:)
hmadgelnvdslitrllevrgcrpgkivqmteaevrglciksreiflsqpilleleaplk
icgdihgqytdllrlfeyggfppeanylflgdyvdrgkqsleticlllaykikypenffl
lrgnhecasinriygfydeckrrfniklwktftdcfnclpiaaivdekifcchgglspdl
qsmeqirrimrptdvpdtgllcdllwsdpdkdvqgwgendrgvsftfgadvvskflnrhd
ldlicrahqvvedgyeffakrqlvtlfsapnycgefdnaggmmsvdetlmcsfqilkpse
kkakyqygg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1s70B (B:)
mkmadakqkrneqlkrwigsetdleppvvkrkktkvkfddgavflaacssgdteevlrll
ergadinyanvdgltalhqaciddnvdmvkflvenganinqpdnegwiplhaaascgyld
iaeylisqgahvgavnsegdtpldiaeeeameellqnevnrqgvdieaarkeeerimlrd
arqwlnsghindvrhaksggtalhvaaakgytevlklliqarydvnikdydgwtplhaaa
hwgkeeacrilvenlcdmeavnkvgqtafdvadedilgyleelqkkqnllhsekrekks

    Sequence, based on observed residues (ATOM records): (download) 
    >1s70B (B:)
mkmadakqkrneqlkrwigsetdleppvvkrkktkvkfddgavflaacssgdteevlrll
ergadinyanvdgltalhqaciddnvdmvkflvenganinqpdnegwiplhaaascgyld
iaeylisqgahvgavnsegdtpldiaeeeameellqnevnrqgvdieaarkeeerimlrd
arqwlnsghindvrhaksggtalhvaaakgytevlklliqarydvnikdydgwtplhaaa
hwgkeeacrilvenlcdmeavnkvgqtafdvadedilgyleelqkkqnllh