PDB entry 1s3y

View 1s3y on RCSB PDB site
Description: Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
Class: oxidoreductase
Keywords: pneumocystis carinii dihydrofolate reductase, inhibitors, stereochemistry
Deposited on 2004-01-14, released 2004-03-30
The last revision prior to the SCOP 1.75 freeze date was dated 2004-03-30, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.233
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: PNEUMOCYSTIS CARINII
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1s3ya_
  • Heterogens: NAP, TQT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1s3yA (A:)
    mnqqksltlivalttsygigrsnslpwklkkeisyfkrvtsfvptfdsfesmnvvlmgrk
    twesiplqfrplkgrinvvitrnesldlgngihsaksldhalellyrtygsessvqinri
    fviggaqlykaamdhpkldrimatiiykdihcdvffplkfrdkewssvwkkekhsdlesw
    vgtkvphgkinedgfdyefemwtrdl