PDB entry 1s1x

View 1s1x on RCSB PDB site
Description: Crystal structure of V108I mutant HIV-1 reverse transcriptase in complex with nevirapine
Class: transferase
Keywords: hiv-1 reverse transcriptase, aids, nnrti, nevirapine, drug resistance mutations, transferase
Deposited on 2004-01-07, released 2004-06-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.235
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: reverse transcriptase
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585
      • engineered (107)
      • modified residue (279)
    Domains in SCOPe 2.08: d1s1xa1, d1s1xa2
  • Chain 'B':
    Compound: reverse transcriptase
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585
      • engineered (107)
    Domains in SCOPe 2.08: d1s1xb1
  • Heterogens: NVP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1s1xA (A:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtildvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelq
aiylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahk
giggneqvdklvsagirkvl

    Sequence, based on observed residues (ATOM records): (download) 
    >1s1xA (A:)
ispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvf
aikkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtildvgdayfsvpldedfrk
ytaftipsinnetiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddly
vgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpe
kdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenre
ilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkql
teavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyq
lekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelqaiylalqd
sglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahkgiggneqv
dklvsa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1s1xB (B:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtildvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyqlekepivgaetf

    Sequence, based on observed residues (ATOM records): (download) 
    >1s1xB (B:)
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfwhpaglkkkksvtildvgdayfsvpldedfrkytafti
psinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvgsd
leigqhrtkieelrqhllrwgltelhpdkwtvqpivlpekdswtvndiqklvgklnwasq
iypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaei
qkqgqgqwtyqiyqepfknlktgkyarmrgtndvkqlteavqkittesiviwgktpkfkl
piqketwetwwteywqatwipewefvntpplvklwyq