PDB entry 1s1t

View 1s1t on RCSB PDB site
Description: Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with UC-781
Class: transferase
Keywords: hiv-1 reverse transcriptase, aids, nnrti, uc-781, drug resistance mutations
Deposited on 2004-01-07, released 2004-06-29
The last revision prior to the SCOP 1.73 freeze date was dated 2004-06-29, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.206
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: reverse transcriptase
    Species: Human immunodeficiency virus type 1 (isolate HXB2)
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585
      • engineered (99)
      • modified residue (279)
    Domains in SCOP 1.73: d1s1ta1, d1s1ta2
  • Chain 'B':
    Compound: reverse transcriptase
    Species: Human immunodeficiency virus type 1 (isolate HXB2)
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585 (Start-439)
      • engineered (99)
    Domains in SCOP 1.73: d1s1tb1
  • Heterogens: PO4, UC1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1s1tA (A:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpagikkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelq
aiylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahk
giggneqvdklvsagirkvl

    Sequence, based on observed residues (ATOM records): (download) 
    >1s1tA (A:)
spietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfa
ikwrklvdfrelnkrtqdfwevqlgiphpagikkkksvtvldvgdayfsvpldedfrkyt
aftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddly
vgsdleigqhrtkieelrqhllrwglttpkkhqkeppflwmgyelhpdkwtvqpivlpek
dswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenrei
lkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlt
eavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyql
ekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelqaiylalqds
glevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahkgig

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1s1tB (B:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpagikkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyqlekepivgaetf

    Sequence, based on observed residues (ATOM records): (download) 
    >1s1tB (B:)
pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfai
kkkdstkwrklvdfrelnkrtqdfwgiphpagikkkksvtvldvgdayfsvpldedfrky
taftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddl
yvgsdleigqhrtkieelrqhllrwgltelhpdkwtvqpivlpekdswtvndiqklvgkl
nwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskd
liaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwg
ktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetf