PDB entry 1rzj

View 1rzj on RCSB PDB site
Description: hiv-1 hxbc2 gp120 envelope glycoprotein complexed with cd4 and induced neutralizing antibody 17b
Class: Viral protein/Immune system
Keywords: COMPLEX (HIV ENVELOPE PROTEIN-CD4-FAB); HIV-1 EXTERIOR ENVELOPE GP120 FROM LABORATORY-ADAPTED ISOLATE; HXBC2; SURFACE T-CELL GLYCOPROTEIN CD4; ANTIGEN-BINDING FRAGMENT OF HUMAN IMMUNOGLOBULIN 17B, Viral protein-Immune system COMPLEX
Deposited on 2003-12-24, released 2004-02-03
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.262
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: T-cell surface glycoprotein cd4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1rzjc1, d1rzjc2
  • Chain 'G':
    Compound: envelope glycoprotein gp120
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04578 (52-320)
      • insertion (4-51)
    Domains in SCOPe 2.04: d1rzjg_
  • Chain 'H':
    Compound: antibody 17b, heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1RZJ (0-228)
    Domains in SCOPe 2.04: d1rzjh1, d1rzjh2
  • Chain 'L':
    Compound: antibody 17b, light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1RZJ (0-213)
    Domains in SCOPe 2.04: d1rzjl1, d1rzjl2
  • Heterogens: NDG, NAG, IPA, HOH

PDB Chain Sequences:

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1rzjC (C:)
    kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
    lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
    ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
    kasnt
    

    Sequence, based on observed residues (ATOM records): (download)
    >1rzjC (C:)
    kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
    lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
    ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
    k
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >1rzjG (G:)
    garsevvlvnvtenfnmwkndmveqmhediislwdqslkpcvkltplcvgagscntsvit
    qacpkvsfepipihycapagfailkcnnktfngtgpctnvstvqcthgirpvvstqllln
    gslaeeevvirsvnftdnaktiivqlntsveinctgaghcnisrakwnntlkqiasklre
    qfgnnktiifkqssggdpeivthsfncggeffycnstqlfnstwfnstwstegsnntegs
    dtitlpcrikqiinmwqkvgkamyappisgqircssnitgllltrdggnsnneseifrpg
    ggdmrdnwrselykykvvkie
    

    Sequence, based on observed residues (ATOM records): (download)
    >1rzjG (G:)
    evvlvnvtenfnmwkndmveqmhediislwdqslkpcvkltplcvgagscntsvitqacp
    kvsfepipihycapagfailkcnnktfngtgpctnvstvqcthgirpvvstqlllngsla
    eeevvirsvnftdnaktiivqlntsveinctgaghcnisrakwnntlkqiasklreqfgn
    nktiifkqssggdpeivthsfncggeffycnstqlfnstwfngsdtitlpcrikqiinmw
    qkvgkamyappisgqircssnitgllltrdggnsnneseifrpgggdmrdnwrselykyk
    vvkie
    

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1rzjH (H:)
    evqlvesgaevkkpgssvkvsckasgdtfirysftwvrqapgqglewmgriitildvahy
    aphlqgrvtitadkststvylelrnlrsddtavyfcagvyegeadegeydnngflkhwgq
    gtlvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvht
    fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk
    

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1rzjL (L:)
    divmtqspatlsvspgeratlscrasesvssdlawyqqkpgqaprlliygastratgvpa
    rfsgsgsgaeftltisslqsedfavyycqqynnwpprytfgqgtrleikrtvaapsvfif
    ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
    ltlskadyekhkvyacevthqglsspvtksfnrg