PDB entry 1rzj

View 1rzj on RCSB PDB site
Description: hiv-1 hxbc2 gp120 envelope glycoprotein complexed with cd4 and induced neutralizing antibody 17b
Class: Viral protein/Immune system
Keywords: complex (hiv envelope protein/cd4/fab); hiv-1 exterior envelope gp120 from laboratory-adapted isolate; hxbc2; surface T-cell glycoprotein cd4; antigen-binding fragment of human immunoglobulin 17b
Deposited on 2003-12-24, released 2004-02-03
The last revision prior to the SCOP 1.75 freeze date was dated 2005-02-01, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.262
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: T-cell surface glycoprotein cd4
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1rzjc1, d1rzjc2
  • Chain 'G':
    Compound: envelope glycoprotein gp120
    Species: HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04578 (52-320)
      • insertion (4-51)
    Domains in SCOP 1.75: d1rzjg_
  • Chain 'H':
    Compound: antibody 17b, heavy chain
    Species: HOMO SAPIENS
    Domains in SCOP 1.75: d1rzjh1, d1rzjh2
  • Chain 'L':
    Compound: antibody 17b, light chain
    Species: HOMO SAPIENS
    Domains in SCOP 1.75: d1rzjl1, d1rzjl2
  • Heterogens: NDG, NAG, IPA, HOH

PDB Chain Sequences:

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1rzjC (C:)
    kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
    lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
    ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
    kasnt
    

    Sequence, based on observed residues (ATOM records): (download)
    >1rzjC (C:)
    kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
    lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
    ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
    k
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >1rzjG (G:)
    garsevvlvnvtenfnmwkndmveqmhediislwdqslkpcvkltplcvgagscntsvit
    qacpkvsfepipihycapagfailkcnnktfngtgpctnvstvqcthgirpvvstqllln
    gslaeeevvirsvnftdnaktiivqlntsveinctgaghcnisrakwnntlkqiasklre
    qfgnnktiifkqssggdpeivthsfncggeffycnstqlfnstwfnstwstegsnntegs
    dtitlpcrikqiinmwqkvgkamyappisgqircssnitgllltrdggnsnneseifrpg
    ggdmrdnwrselykykvvkie
    

    Sequence, based on observed residues (ATOM records): (download)
    >1rzjG (G:)
    evvlvnvtenfnmwkndmveqmhediislwdqslkpcvkltplcvgagscntsvitqacp
    kvsfepipihycapagfailkcnnktfngtgpctnvstvqcthgirpvvstqlllngsla
    eeevvirsvnftdnaktiivqlntsveinctgaghcnisrakwnntlkqiasklreqfgn
    nktiifkqssggdpeivthsfncggeffycnstqlfnstwfngsdtitlpcrikqiinmw
    qkvgkamyappisgqircssnitgllltrdggnsnneseifrpgggdmrdnwrselykyk
    vvkie
    

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1rzjH (H:)
    evqlvesgaevkkpgssvkvsckasgdtfirysftwvrqapgqglewmgriitildvahy
    aphlqgrvtitadkststvylelrnlrsddtavyfcagvyegeadegeydnngflkhwgq
    gtlvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvht
    fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk
    

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1rzjL (L:)
    divmtqspatlsvspgeratlscrasesvssdlawyqqkpgqaprlliygastratgvpa
    rfsgsgsgaeftltisslqsedfavyycqqynnwpprytfgqgtrleikrtvaapsvfif
    ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
    ltlskadyekhkvyacevthqglsspvtksfnrg