PDB entry 1rwv

View 1rwv on RCSB PDB site
Description: Crystal structure of human caspase-1 in complex with 5-[5-(1-carboxymethyl-2-oxo-propylcarbamoyl)-5-phenyl-pentylsulfamoyl]-2-hydroxy-benzoic acid
Class: hydrolase
Keywords: protein-small molecule inhibitor complex, HYDROLASE
Deposited on 2003-12-17, released 2004-12-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.2
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Interleukin-1 beta convertase
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP1, IL1BC, IL1BCE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1rwv.1
  • Chain 'B':
    Compound: Interleukin-1 beta convertase
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP1, IL1BC, IL1BCE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1rwv.1
  • Heterogens: 5PH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1rwvA (A:)
    npamptssgsegnvklcsleeaqriwkqksaeiypimdkssrtrlaliicneefdsiprr
    tgaevditgmtmllqnlgysvdvkknltasdmtteleafahrpehktsdstflvfmshgi
    regicgkkhseqvpdilqlnaifnmlntkncpslkdkpkviiiqacrgdspgvvwfkd
    

    Sequence, based on observed residues (ATOM records): (download)
    >1rwvA (A:)
    tssgsegnvklcsleeaqriwkqksaeiypimdkssrtrlaliicneefdsiprrtgaev
    ditgmtmllqnlgysvdvkknltasdmtteleafahrpehktsdstflvfmshgiregic
    gkkhseqvpdilqlnaifnmlntkncpslkdkpkviiiqacrgdspgvvwfkd
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1rwvB (B:)
    aikkahiekdfiafcsstpdnvswrhptmgsvfigrliehmqeyacscdveeifrkvrfs
    feqpdgraqmpttervtltrcfylfpgh