PDB entry 1rr8
View 1rr8 on RCSB PDB site
Description: Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I
Class: isomerase/DNA
Keywords: Protein-DNA complex, Topotecan, Camptothecin, Nucleic Acid, Human Topoisomerase I, ISOMERASE/DNA COMPLEX
Deposited on
2003-12-08, released
2004-07-06
The last revision prior to the SCOPe 2.02 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.242
AEROSPACI score: 0.26
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: 5'-d(*ap*ap*ap*ap*ap*gp*ap*cp*tp*t*gp*gp*ap*ap*ap*ap*ap*tp*tp*tp*tp*t)-3'
- Chain 'B':
Compound: 5'-d(*ap*ap*ap*ap*ap*tp*tp*tp*tp*tp*cp*cp*ap*ap*gp*tp*cp*tp*tp*tp*tp*t)-3'
- Chain 'C':
Compound: DNA topoisomerase I
Species: Homo sapiens [TaxId:9606]
Gene: TOP1
Database cross-references and differences (RAF-indexed):
- Uniprot P11387 (2-564)
- cloning artifact (0-1)
- engineered (160)
- engineered (433)
- modified residue (522)
Domains in SCOPe 2.02: d1rr8c1, d1rr8c2 - Heterogens: TTG, HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
No sequence available.
- Chain 'C':
Sequence, based on SEQRES records: (download)
>1rr8C (C:)
aawkwweeerypegikwkflehkgpvfappyeplpenvkfyydgkvmklspkaeevatff
akmldheyttkeifrknffkdwrkemtneekniitnlskcdftqmsqyfkaqtearkqms
keeklkikeenekllkeygfcimdnhkerianfkieppglsrgrgnhpkmgmlkrrimpe
diiincskdakvpspppghkwkevrhdnkvtwlvswteniqgsikyimlnpssrikgekd
wqkyetarrlkkcvdkirnqyredwkskemkvrqravalyfidklalragnekeegetad
tvgccslrvehinlhpeldgqeyvvefdflgkdsiryynkvpvekrvfknlqlfmenkqp
eddlfdrlntgilnkhlqdlmegltakvfrtynasitlqqqlkeltapdenipakilsyn
ranravailcnhqqappktfeksmmnlqtkidakkeqladarrdlksakadakvmkdakt
kkvveskkkavqrleeqlmklevqatdreenkqialgtsklnyldpritvawckkwgvpi
ekiynktqrekfawaidmadedyef
Sequence, based on observed residues (ATOM records): (download)
>1rr8C (C:)
aawkwweeerypegikwkflehkgpvfappyeplpenvkfyydgkvmklspkaeevatff
akmldheyttkeifrknffkdwrkemtneekniitnlskcdftqmsqyfkaqtearkqms
keeklkikeenekllkeygfcimdnhkerianfkieppglsrgrgnhpkmgmlkrrimpe
diiincskdakvpspppghkwkevrhdnkvtwlvswteniqgsikyimlnpssrikgekd
wqkyetarrlkkcvdkirnqyredwkskemkvrqravalyfidklalragnekeegetad
tvgccslrvehinlhpeldgqeyvvefdflgkdsiryynkvpvekrvfknlqlfmenkqp
eddlfdrlntgilnkhlqdlmegltakvfrtynasitlqqqlkeltapdenipakilsyn
ranravailcnhqqapreenkqialgtsklnyldpritvawckkwgvpiekiynktqrek
fawaidmadedyef