PDB entry 1rqd

View 1rqd on RCSB PDB site
Description: deoxyhypusine synthase holoenzyme in its low ionic strength, high pH crystal form with the inhibitor GC7 bound in the active site
Class: Transferase
Keywords: Rossmann Fold, NAD cofactor, deoxyhypusine, hypusine, spermidine, GC7, Transferase
Deposited on 2003-12-04, released 2004-07-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-11-12, with a file datestamp of 2014-11-07.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.196
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: deoxyhypusine synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: DHPS, DS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1rqda_
  • Chain 'B':
    Compound: deoxyhypusine synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: DHPS, DS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1rqdb_
  • Heterogens: NAD, GC7

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1rqdA (A:)
megslereapagalaavlkhsstlppestqvrgydfnrgvnyralleafgttgfqatnfg
ravqqvnamiekkleplsqdedqhadltqsrrpltsctiflgytsnlissgiretirylv
qhnmvdvlvttaggveedlikclaptylgefslrgkelrenginrignllvpnenyckfe
dwlmpildqmvmeqntegvkwtpskmiarlgkeinnpesvyywaqknhipvfspaltdgs
lgdmiffhsyknpglvldivedlrlintqaifakctgmiilgggvvkhhiananlmrnga
dyavyintaqefdgsdsgarpdeavswgkirvdaqpvkvyadaslvfpllvaetfaqkmd
afmhekned

    Sequence, based on observed residues (ATOM records): (download) 
    >1rqdA (A:)
stqvrgydfnrgvnyralleafgttgfqatnfgravqqvnamiekkleplsqdedqhadl
tqsrrpltsctiflgytsnlissgiretirylvqhnmvdvlvttaggveedlikclapty
lgefslrgkelrenginrignllvpnenyckfedwlmpildqmvmeqntegvkwtpskmi
arlgkeinnpesvyywaqknhipvfspaltdgslgdmiffhsyknpglvldivedlrlin
tqaifakctgmiilgggvvkhhiananlmrngadyavyintaqefdgsdsgarpdeavsw
gkirvdaqpvkvyadaslvfpllvaetfaqkmdafmh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1rqdB (B:)
megslereapagalaavlkhsstlppestqvrgydfnrgvnyralleafgttgfqatnfg
ravqqvnamiekkleplsqdedqhadltqsrrpltsctiflgytsnlissgiretirylv
qhnmvdvlvttaggveedlikclaptylgefslrgkelrenginrignllvpnenyckfe
dwlmpildqmvmeqntegvkwtpskmiarlgkeinnpesvyywaqknhipvfspaltdgs
lgdmiffhsyknpglvldivedlrlintqaifakctgmiilgggvvkhhiananlmrnga
dyavyintaqefdgsdsgarpdeavswgkirvdaqpvkvyadaslvfpllvaetfaqkmd
afmhekned

    Sequence, based on observed residues (ATOM records): (download) 
    >1rqdB (B:)
stqvrgydfnrgvnyralleafgttgfqatnfgravqqvnamiekkleplpltsctiflg
ytsnlissgiretirylvqhnmvdvlvttaggveedlikclaptylgefslrgkelreng
inrignllvpnenyckfedwlmpildqmvmeqntegvkwtpskmiarlgkeinnpesvyy
waqknhipvfspaltdgslgdmiffhsyknpglvldivedlrlintqaifakctgmiilg
ggvvkhhiananlmrngadyavyintaqefdgsdsgarpdeavswgkirvdaqpvkvyad
aslvfpllvaetfaqkmdafm