PDB entry 1r9n

View 1r9n on RCSB PDB site
Description: Crystal Structure of human dipeptidyl peptidase IV in complex with a decapeptide (tNPY) at 2.3 Ang. Resolution
Class: hydrolase
Keywords: alpha/beta Hydrolase, Eight-bladed beta propeller, Serine Protease, hydrolase
Deposited on 2003-10-30, released 2005-03-29
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.213
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dipeptidyl peptidase IV
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1r9na1, d1r9na2
  • Chain 'B':
    Compound: dipeptidyl peptidase IV
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27487 (11-738)
      • expression tag (8-10)
    Domains in SCOPe 2.05: d1r9nb1, d1r9nb2
  • Chain 'C':
    Compound: dipeptidyl peptidase IV
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1r9nc1, d1r9nc2
  • Chain 'D':
    Compound: dipeptidyl peptidase IV
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1r9nd1, d1r9nd2
  • Chain 'E':
    Compound: neuropeptide y
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: neuropeptide y
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: neuropeptide y
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: neuropeptide y
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1r9nA (A:)
adpggshhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnss
vflenstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteer
ipnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeev
fsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvk
ffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdi
cdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyf
qidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclsc
elnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnv
qmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatyl
asteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiw
gwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnst
vmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiassta
hqhiythmshfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >1r9nA (A:)
srktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfdef
ghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtws
pvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwsp
ngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslss
vtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwn
clvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfit
kgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyys
vsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfii
lnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasf
dgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsm
vlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqv
eyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshf
ikqcfslp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1r9nB (B:)
adpggshhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnss
vflenstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteer
ipnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeev
fsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvk
ffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdi
cdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyf
qidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclsc
elnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnv
qmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatyl
asteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiw
gwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnst
vmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiassta
hqhiythmshfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >1r9nB (B:)
hhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstf
defghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwv
twspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalw
wspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntds
lssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessg
rwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdct
fitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercq
yysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkld
fiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniiv
asfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyv
tsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenf
kqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythm
shfikqcfslp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1r9nC (C:)
adpggshhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnss
vflenstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteer
ipnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeev
fsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvk
ffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdi
cdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyf
qidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclsc
elnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnv
qmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatyl
asteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiw
gwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnst
vmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiassta
hqhiythmshfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >1r9nC (C:)
rktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfdefg
hsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwsp
vghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspn
gtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssv
tnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnc
lvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfitk
gtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysv
sfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiil
netkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfd
grgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmv
lgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqve
yllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfi
kqcfslp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1r9nD (D:)
adpggshhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnss
vflenstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteer
ipnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeev
fsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvk
ffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdi
cdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyf
qidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclsc
elnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnv
qmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatyl
asteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiw
gwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnst
vmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiassta
hqhiythmshfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >1r9nD (D:)
rktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfdefg
hsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwsp
vghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspn
gtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssv
tnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnc
lvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfitk
gtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysv
sfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiil
netkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfd
grgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmv
lgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqve
yllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfi
kqcfslp

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.