PDB entry 1r6u

View 1r6u on RCSB PDB site
Description: Crystal structure of an active fragment of human tryptophanyl-tRNA synthetase with cytokine activity
Class: ligase
Keywords: Class Ic tRNA synthetase, Rossmann fold catalytic domain, anticodon recognition domain, bound Trp-AMP, LIGASE
Deposited on 2003-10-16, released 2004-01-06
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.254
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tryptophanyl-tRNA synthetase
    Species: Homo sapiens [TaxId:9606]
    Gene: WARS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23381
      • modified residue (95)
      • modified residue (121)
      • modified residue (147)
      • engineered (165-166)
      • modified residue (193)
      • modified residue (195)
      • modified residue (271)
      • modified residue (302)
      • modified residue (353)
      • modified residue (377)
      • modified residue (413)
    Domains in SCOPe 2.01: d1r6ua_
  • Chain 'B':
    Compound: Tryptophanyl-tRNA synthetase
    Species: Homo sapiens [TaxId:9606]
    Gene: WARS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23381
      • modified residue (95)
      • modified residue (121)
      • modified residue (147)
      • engineered (165-166)
      • modified residue (193)
      • modified residue (195)
      • modified residue (271)
      • modified residue (353)
      • modified residue (377)
      • modified residue (413)
    Domains in SCOPe 2.01: d1r6ub_
  • Heterogens: TYM, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1r6uA (A:)
msykaaagedykadcppgnpaptsnhgpdateaeedfvdpwtvqtssakgidydklivrf
gsskidkelinrieratgqrphhflrrgiffshrdmnqvldayenkkpfylytgrgpsse
amhvghlipfiftkwlqdvfnvplviqmtddekylwkdltldqaygdavenakdiiacgf
dinktfifsdldymgmssgfyknvvkiqkhvtfnqvkgifgftdsdcigkisfpaiqaap
sfsnsfpqifrdrtdiqclipcaidqdpyfrmtrdvaprigypkpallhstffpalqgaq
tkmsasdpnssifltdtakqiktkvnkhafsggrdtieehrqfggncdvdvsfmyltffl
edddkleqirkdytsgamltgelkkalievlqpliaehqarrkevtdeivkefmtprkls
fdfqklaaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >1r6uA (A:)
edfvdpwtvqtssakgidydklivrfgsskidkelinrieratgqrphhflrrgiffshr
dmnqvldayenkkpfylytgrgpsseamhvghlipfiftkwlqdvfnvplviqmtddeky
lwkdltldqaygdavenakdiiacgfdinktfifsdldymgmssgfyknvvkiqkhvtfn
qvkgifgftdsdcigkisfpaiqaapsfsnsfpqifrdrtdiqclipcaidqdpyfrmtr
dvaprigypkpallhstffpalqgaqtkmsasdpnssifltdtakqiktkvnkhafsggr
dtieehrqfggncdvdvsfmyltffledddkleqirkdytsgamltgelkkalievlqpl
iaehqarrkevtdeivkefmtprklsfd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1r6uB (B:)
msykaaagedykadcppgnpaptsnhgpdateaeedfvdpwtvqtssakgidydklivrf
gsskidkelinrieratgqrphhflrrgiffshrdmnqvldayenkkpfylytgrgpsse
amhvghlipfiftkwlqdvfnvplviqmtddekylwkdltldqaygdavenakdiiacgf
dinktfifsdldymgmssgfyknvvkiqkhvtfnqvkgifgftdsdcigkisfpaiqaap
sfsnsfpqifrdrtdiqclipcaidqdpyfrmtrdvaprigypkpallhstffpalqgaq
tkmsasdpnssifltdtakqiktkvnkhafsggrdtieehrqfggncdvdvsfmyltffl
edddkleqirkdytsgamltgelkkalievlqpliaehqarrkevtdeivkefmtprkls
fdfqklaaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >1r6uB (B:)
gidydklivrfgsskidkelinrieratgqrphhflrrgiffshrdmnqvldayenkkpf
ylytgrgpsseamhvghlipfiftkwlqdvfnvplviqmtddekylwkdltldqaygdav
enakdiiacgfdinktfifsdldymgmssgfyknvvkiqkhvtfnqvkgifgftdsdcig
kisfpaiqaapsfsnsfpqifrdrtdiqclipcaidqdpyfrmtrdvaprigypkpallh
stffpalqgpnssifltdtakqiktkvnkhafsggrdtieehrqfggncdvdvsfmyltf
fledddkleqirkdytsgamltgelkkalievlqpliaehqarrkevtdeivkefmtprk
ls