PDB entry 1qs8

View 1qs8 on RCSB PDB site
Description: Crystal structure of the P. vivax aspartic proteinase plasmepsin complexed with the inhibitor pepstatin A
Class: hydrolase/hydrolase inhibitor
Keywords: PLASMEPSIN, ASPARTIC PROTEINASE, HAEMOGLOBINASE, MALARIA, PEPSTATIN A, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 1999-06-25, released 1999-07-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.197
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: plasmepsin
    Species: Plasmodium vivax [TaxId:5855]
    Database cross-references and differences (RAF-indexed):
    • gb g3095034 (2-328)
    Domains in SCOPe 2.08: d1qs8a_
  • Chain 'B':
    Compound: plasmepsin
    Species: Plasmodium vivax [TaxId:5855]
    Database cross-references and differences (RAF-indexed):
    • gb g3095034 (2-328)
    Domains in SCOPe 2.08: d1qs8b_
  • Chain 'C':
    Compound: pepstatin A
    Database cross-references and differences (RAF-indexed):
    • PDB 1QS8
  • Chain 'D':
    Compound: pepstatin A
    Database cross-references and differences (RAF-indexed):
    • PDB 1QS8 (0-5)
  • Heterogens: ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1qs8A (A:)
lgsendvielddvanimfygegevgdnhqkfmlifdtgsanlwvpskkcnssgcsiknly
dssksksyekdgtkvditygsgtvkgffskdlvtlghlsmpykfievidtddlepiyssv
efdgilglgwkdlsigsidpivvelknqnkidnalftfylpvhdvhagyltiggieekfy
egnityeklnhdlywqidldvhfgkqtmekanvivdsgtttitapseflnkffanlnvik
vpflpfyvttcdnkemptlefksanntytlepeyymnpilevddtlcmitmlpvdidsnt
filgdpfmrkyftvfdydkesvgfaiakn

    Sequence, based on observed residues (ATOM records): (download) 
    >1qs8A (A:)
sendvielddvanimfygegevgdnhqkfmlifdtgsanlwvpskkcnssgcsiknlyds
sksksyekdgtkvditygsgtvkgffskdlvtlghlsmpykfievidtddlepiyssvef
dgilglgwkdlsigsidpivvelknqnkidnalftfylpvhdvhagyltiggieekfyeg
nityeklnhdlywqidldvhfgkqtmekanvivdsgtttitapseflnkffanlnvikvp
flpfyvttcdnkemptlefksanntytlepeyymnpilevddtlcmitmlpvdidsntfi
lgdpfmrkyftvfdydkesvgfaiakn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1qs8B (B:)
lgsendvielddvanimfygegevgdnhqkfmlifdtgsanlwvpskkcnssgcsiknly
dssksksyekdgtkvditygsgtvkgffskdlvtlghlsmpykfievidtddlepiyssv
efdgilglgwkdlsigsidpivvelknqnkidnalftfylpvhdvhagyltiggieekfy
egnityeklnhdlywqidldvhfgkqtmekanvivdsgtttitapseflnkffanlnvik
vpflpfyvttcdnkemptlefksanntytlepeyymnpilevddtlcmitmlpvdidsnt
filgdpfmrkyftvfdydkesvgfaiakn

    Sequence, based on observed residues (ATOM records): (download) 
    >1qs8B (B:)
gsendvielddvanimfygegevgdnhqkfmlifdtgsanlwvpskkcnssgcsiknlyd
ssksksyekdgtkvditygsgtvkgffskdlvtlghlsmpykfievidtddlepiyssve
fdgilglgwkdlsigsidpivvelknqnkidnalftfylpvhdvhagyltiggieekfye
gnityeklnhdlywqidldvhfgkqtmekanvivdsgtttitapseflnkffanlnvikv
pflpfyvttcdnkemptlefksanntytlepeyymnpilevddtlcmitmlpvdidsntf
ilgdpfmrkyftvfdydkesvgfaiakn

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.